ID G5IAV8_9CLOT Unreviewed; 444 AA.
AC G5IAV8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Altronate oxidoreductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9473_00635 {ECO:0000313|EMBL:EHI61273.1};
OS Hungatella hathewayi WAL-18680.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hungatella.
OX NCBI_TaxID=742737 {ECO:0000313|EMBL:EHI61273.1, ECO:0000313|Proteomes:UP000005384};
RN [1] {ECO:0000313|EMBL:EHI61273.1, ECO:0000313|Proteomes:UP000005384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAL-18680 {ECO:0000313|EMBL:EHI61273.1,
RC ECO:0000313|Proteomes:UP000005384};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA Molitoris D.R., Song M., Daigneault M., Allen-Vercoe E., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium hathewayi WAL-18680.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate
CC + H(+) + NADH; Xref=Rhea:RHEA:19661, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57634, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:61381; EC=1.1.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000292};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI61273.1}.
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DR EMBL; ADLN01000005; EHI61273.1; -; Genomic_DNA.
DR RefSeq; WP_006778620.1; NZ_JH379027.1.
DR AlphaFoldDB; G5IAV8; -.
DR PATRIC; fig|742737.3.peg.636; -.
DR HOGENOM; CLU_027324_1_0_9; -.
DR OrthoDB; 9768714at2; -.
DR Proteomes; UP000005384; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013118; Mannitol_DH_C.
DR InterPro; IPR013131; Mannitol_DH_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR30524:SF0; ALTRONATE OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR30524; MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE; 1.
DR Pfam; PF01232; Mannitol_dh; 1.
DR Pfam; PF08125; Mannitol_dh_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000005384}.
FT DOMAIN 7..157
FT /note="Mannitol dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01232"
FT DOMAIN 190..385
FT /note="Mannitol dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08125"
SQ SEQUENCE 444 AA; 50801 MW; 656B261150A472D7 CRC64;
MSNSKETVMQ FGEGGFLRGF VDYFFHKLQE KGLYDGKIVV VQPIEKGMCQ MLADQNCEYN
LFLRGIDNGQ VVNEHTHVTS ISRALNPYTQ YEEYMKLAEN PDLRVIVSNT TEAGIEYLGT
EKLTDTPPKS YPAKLTQFLY KRFQLGLKGF ILLPCELIDN NADNLKKCIL QYADLWELGS
DFKNWLESEN DFCNTLVDRI VTGYPRDEVE ELTKQIGYTD NLIDTAEIFH LWVIEGHHED
ELPFNKAGYN IVWTDDAKPY KKRKVRILNG GHTSMVLGAR LYGLSTVGEC LKDETVSAFL
KKCIFEEIVP TLGNTETDVK FGEAVLERFS NPFIKHQLLS IALNSVSKFQ VRVLPTILEY
KEKFGKYPAA LTFSMAALIA FYRTDEANDG ADIMEFMKTA SVEDIMKRED YWHSDLTEMI
PLVTEYYNMI QEKGMAEAYK AVLA
//
