ID G5IC87_9CLOT Unreviewed; 855 AA.
AC G5IC87;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
GN ORFNames=HMPREF9473_01070 {ECO:0000313|EMBL:EHI61005.1};
OS Hungatella hathewayi WAL-18680.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; Hungatella.
OX NCBI_TaxID=742737 {ECO:0000313|EMBL:EHI61005.1, ECO:0000313|Proteomes:UP000005384};
RN [1] {ECO:0000313|EMBL:EHI61005.1, ECO:0000313|Proteomes:UP000005384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAL-18680 {ECO:0000313|EMBL:EHI61005.1,
RC ECO:0000313|Proteomes:UP000005384};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA Molitoris D.R., Song M., Daigneault M., Allen-Vercoe E., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium hathewayi WAL-18680.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI61005.1}.
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DR EMBL; ADLN01000009; EHI61005.1; -; Genomic_DNA.
DR RefSeq; WP_006779056.1; NZ_JH379027.1.
DR AlphaFoldDB; G5IC87; -.
DR PATRIC; fig|742737.3.peg.1075; -.
DR HOGENOM; CLU_005015_3_2_9; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000005384; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005384}.
FT DOMAIN 244..336
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 785..830
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 855 AA; 97636 MW; 6C676A87D2E72D4B CRC64;
MNLFKMELKD WRVGEYPAGA PDGTTPEVPE EWISASVPGC VQYDLVEQGR LDNPYAGTKG
AFDAAWVAKS DWLYETVFDR PDGLEKMAHV ILKLWGIDTF SEVWLNGSLL GETVNAYRSY
EFSILPEMLL ERGNRLQIRV KAHGRMVEDK LEAAECLTCG KETEGLLGKA LIRRYQRSFY
TNSSLLNVGT GVLGIGINRP VELYGYPGRY LTDVAYTTRE IGDCAEGSIC VSLNPAGEDG
ADQAEKTAEE KCAVQAENLA GEEVVVKAEI LDGEKTCVWE TEYVAGEETT ETAVRIENPK
LWWPRGYGEP YLYTLKVSVW ENGVQTDEKI IQIGIRTVRL VQRTPSGKKT FYIEVNGQKI
FVKGENYIPM DYLKVYGSRE QYDNLFLLTE QQLVNTIRIW GGGAVEDESF FRECDRRGIL
IWHDLFLHSN VYPDYDPEFV ENYKEEVKGV LKTIRSHPCI CLVCGGNEQQ EGWDEWGWKQ
DKERFFGETL PRVHTPVLVE ELCPDIPYIY NSPHGGSLCQ SPAEGDSHCW GNYYNSFKDP
LFVTETCWTT ESYSRPETLE SCMGMDLTEY EGKGWADKWN QFTSLPTFNR RPFSSWFETD
SLRGYLHALE VEQARADYHA LSQLRFTGPS NHGIIYWSFN KGGPLFQFGC VDYGGRPMMS
YYVVKRLYQS VAIFPYREFK DVRVLLSNHL TCEAEVCVEA FHMNRAGEVL NQFRAETVCP
AGETVLALLL EGLYEQVQER TEETVFVRAI MDGVVVSEDL LLFAPYGELQ VDSRPMDARM
EKTGEREWEL TVHSEGIVQM VEIECDRKMV CEDNYFPMMT GERKTVKMIL LEECGGRQPE
FLIRKLGEKN SIKLH
//