ID G5JK08_9STAP Unreviewed; 186 AA.
AC G5JK08;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR {ECO:0000256|ARBA:ARBA00014341};
DE AltName: Full=Intercellular adhesion protein R {ECO:0000256|ARBA:ARBA00030200};
GN ORFNames=SS7213T_09097 {ECO:0000313|EMBL:EHJ07498.1};
OS Staphylococcus simiae CCM 7213 = CCUG 51256.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=911238 {ECO:0000313|EMBL:EHJ07498.1, ECO:0000313|Proteomes:UP000005413};
RN [1] {ECO:0000313|EMBL:EHJ07498.1, ECO:0000313|Proteomes:UP000005413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 7213 {ECO:0000313|EMBL:EHJ07498.1,
RC ECO:0000313|Proteomes:UP000005413};
RX PubMed=22272658; DOI=10.1186/1471-2164-13-38;
RA Suzuki H., Lefebure T., Pavinski Bitar P., Stanhope M.J.;
RT "Comparative genomic analysis of the genus Staphylococcus including
RT Staphylococcus aureus and its newly described sister species Staphylococcus
RT simiae.";
RL BMC Genomics 13:38-38(2012).
CC -!- FUNCTION: Represses transcription of the icaADBC operon necessary for
CC biofilm production. {ECO:0000256|ARBA:ARBA00002291}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHJ07498.1}.
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DR EMBL; AEUN01000464; EHJ07498.1; -; Genomic_DNA.
DR RefSeq; WP_002464513.1; NZ_AEUN01000464.1.
DR AlphaFoldDB; G5JK08; -.
DR PATRIC; fig|911238.3.peg.1587; -.
DR OrthoDB; 509229at2; -.
DR Proteomes; UP000005413; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR041646; IcaR_C.
DR PANTHER; PTHR43479; ACREF/ENVCD OPERON REPRESSOR-RELATED; 1.
DR PANTHER; PTHR43479:SF11; ACREF_ENVCD OPERON REPRESSOR-RELATED; 1.
DR Pfam; PF18665; TetR_C_37; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335}.
FT DOMAIN 1..59
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 22..41
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 186 AA; 22119 MW; B552A2CAEC7C1D6D CRC64;
MKDKIIDNAI TLFSEKGYDG TTLDDIAKSV NIRKASVYYH FGSKKDIYER SVECCFDYLA
NTILINQNKS NYSIDALYQF LFEFIFDVEE RYIRMYVQLS NTPEEFSEDI YNQIQSLNSK
LSDEVSRFYD ETKMTMSEED FKNLILLFLE SWYLKASFSQ KFGEVEESKN RFKDEVYSLL
NIFLKK
//
