ID G5JPD4_STRCG Unreviewed; 356 AA.
AC G5JPD4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Tyrosine recombinase XerS {ECO:0000256|HAMAP-Rule:MF_01816};
GN Name=xerS {ECO:0000256|HAMAP-Rule:MF_01816,
GN ECO:0000313|EMBL:EHI73514.1};
GN ORFNames=STRCR_1586 {ECO:0000313|EMBL:EHI73514.1};
OS Streptococcus criceti HS-6.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=873449 {ECO:0000313|EMBL:EHI73514.1, ECO:0000313|Proteomes:UP000004322};
RN [1] {ECO:0000313|EMBL:EHI73514.1, ECO:0000313|Proteomes:UP000004322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS-6 {ECO:0000313|EMBL:EHI73514.1,
RC ECO:0000313|Proteomes:UP000004322};
RA Stanhope M.J., Durkin A.S., Hostetler J., Kim M., Radune D., Singh I.,
RA Town C.D.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. Essential
CC to convert dimers of the bacterial chromosome into monomers to permit
CC their segregation at cell division. {ECO:0000256|HAMAP-Rule:MF_01816}.
CC -!- ACTIVITY REGULATION: FtsK is required for recombination.
CC {ECO:0000256|HAMAP-Rule:MF_01816}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01816}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerS subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01816}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI73514.1}.
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DR EMBL; AEUV02000002; EHI73514.1; -; Genomic_DNA.
DR RefSeq; WP_004225584.1; NZ_AEUV02000002.1.
DR AlphaFoldDB; G5JPD4; -.
DR STRING; 873449.STRCR_1586; -.
DR eggNOG; COG4974; Bacteria.
DR OrthoDB; 283809at2; -.
DR Proteomes; UP000004322; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR CDD; cd00397; DNA_BRE_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR HAMAP; MF_01816; Recomb_XerS; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR023670; Recomb_XerS.
DR PANTHER; PTHR30349:SF41; INTEGRASE_RECOMBINASE HI_1414-RELATED; 1.
DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01816};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_01816};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW Rule:MF_01816}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01816};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP-
KW Rule:MF_01816};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP-
KW Rule:MF_01816};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01816}.
FT DOMAIN 16..121
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 169..354
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT ACT_SITE 210
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01816"
FT ACT_SITE 234
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01816"
FT ACT_SITE 306
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01816"
FT ACT_SITE 309
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01816"
FT ACT_SITE 332
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01816"
FT ACT_SITE 341
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01816"
SQ SEQUENCE 356 AA; 41537 MW; C810468807D41AD0 CRC64;
MKRERLLEKI EELKALMPWY VLDYYQSKLS IPYSFTTLYE YLKEYRRFFE WLIDADLTDV
KAIADIPLDV LEHLTKKDME TFILYLRERP SLNTYSTKQG VSQTTINRTL SALSSLYKYL
TEEVENDQGE PYFYRNVMKK VSTKKKKETL AARAENIKQK LFLGDETMEF LDYVDKEYEG
KLSNRAKSSF RKNKERDLAI IALLLASGVR LSEAVNLDMK DLNLNMMVIE VTRKGGKRDS
VNVAGFAKPY LEDYLKVRKS RYKAEKQDTA LFLSEYRGVP NRMDASSIEK MVGKYSQDFK
IRVTPHKLRH TLATRLYDAT KSQVLVSHQL GHASTQVTDL YTHIVNDEQK NALDNL
//
