ID G5JUF5_9STRE Unreviewed; 1890 AA.
AC G5JUF5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Putative linear gramicidin synthetase LgrD {ECO:0000313|EMBL:EHJ52051.1};
GN ORFNames=STRMA_0778 {ECO:0000313|EMBL:EHJ52051.1};
OS Streptococcus macacae NCTC 11558.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=764298 {ECO:0000313|EMBL:EHJ52051.1, ECO:0000313|Proteomes:UP000003573};
RN [1] {ECO:0000313|EMBL:EHJ52051.1, ECO:0000313|Proteomes:UP000003573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 11558 {ECO:0000313|EMBL:EHJ52051.1,
RC ECO:0000313|Proteomes:UP000003573};
RX PubMed=24625962; DOI=10.1093/gbe/evu048;
RA Richards V.P., Palmer S.R., Pavinski Bitar P.D., Qin X., Weinstock G.M.,
RA Highlander S.K., Town C.D., Burne R.A., Stanhope M.J.;
RT "Phylogenomics and the dynamic genome evolution of the genus
RT Streptococcus.";
RL Genome Biol. Evol. 6:741-753(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHJ52051.1}.
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DR EMBL; AEUW02000001; EHJ52051.1; -; Genomic_DNA.
DR RefSeq; WP_003079678.1; NZ_UHFV01000002.1.
DR STRING; 764298.STRMA_0778; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000003573; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44845:SF7; PLIPASTATIN SYNTHASE SUBUNIT D; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1425..1500
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1890 AA; 217855 MW; 3D4A698A9B46E0D9 CRC64;
MNDENKKKQK LLNSILKGQI KKERVKEADR LEKTKSKEAP LSYAQKRMWF LHNLNEANDT
YNMHSVLKMT GNLNKDALLY SLLKIVERHD ILRTHFKRDQ TGEPIQVVND DFERTIEVKD
MSTEDEGFIT SYIRHEISKP FDLENDMLIR AVLIKGPSAE CYYLVVTMHH IVSDGWSFAV
LGQELMDYYK RYQKEDYSVD SLDYQYIDYT FWQDQYLASE RLEHQCDYWK RQLLPLPAPL
DLKVKHQEDL AAASEAGRHI VHIDQNQLSA LKSLSTKTGT TLYMVLLTAY AILLNKYSFQ
EDFIIGTPVA NRRRKELENL IGFFVNTLPI RIKLNTGETF EETLQKVKAE TVDAFSNQDI
PFEYIVKEVM GERANDQLPI MQTMFVLQNT NKVDVTLPNV KVENQVYENT TAKFDLLLTA
MEVEQGVRLA FEYKKGLFDA SVVESMANKY LMILDDILQN SRKSLLQIAH EEMAIVNQDS
LFKDTMAFSS CNLIERFSEM VNENANKVAV SYQGQEISYA QLDKRSNQLS RYIDRFLQRD
SGFVGLCMDR SIDMIVGILA ILKSNCAYVP LDPDAPKERQ DFIVKDAKLE LLIGHKEKLA
HIAVQDDIPL IAIDHQSKKI FEESAAPIKL TRKADSNAYM IYTSGSTGNP KGVIVSDNNV
LRLFSNTEEL YHFNNKDVWT MFHSVAFDFS VWEIWGALLY GGELVIVPYE TSRTPDDFLK
LLLDRKVTVL NQTPSAFRQL LQYDTVYSKE TVGQIKLRYI IFGGEALDFK MLDLWIKAYG
DDSPQLVNMY GITETTVHAT YQILNKASIK DNRKSIIGTP IKDLQIYLLD PQMRLVPNGV
IGEMYIGGAG VTKGYWNREK LSAERFIQNP FLNDTNSILY KTGDLACKYP NGDLEYIGRN
DDQVKVKGFR IELNEIQEKV NQSAYVNDSL VILDKDDYDS RIISYFTLDK GKKKEIVQNL
LLKNDYDKET QEVFNHHYLK DNTTGYDTFN ITGWNNSYNN EQMTEAEMQE WLQSISRKLY
EIPMRSVLEI GVGTGMILHK LSHKVKHYVG LDISKEAIDY NKRVIKKNGL NYDNVELLHT
SVENLEKKVN NTFDTVIINS VAQYFPDVSY FEDTLAASIE RIGDYGHIVI GDVRSYDRLD
MYYLSVELSR LDKQASIASL RKNMAIRREN EKELIFAHDY FKLLKDKIPE IVNVDITPKI
GEIDNELSKY RYDVILTIDK EQKDTPTPLH PTVVHWTDST DMAQFLTDDM VHFVKVPDKR
VSNEKLFIEN LRSVNEQMTI ENYMKSLAAD NSLLSIEGKK RVEDLAKKKG YQVYTSVDNV
LGYLDLIVYN PAIVEKKAII QYLNNYYSCD SSKAKTTDPL KYKIQYTVIE HLKEALKDKL
PYYMIPNEFL LIDHIPLTIN GKIDYKALPK LNNSGNQLLT QKEDWCEDYV IETVTKVWEN
LLHLENISPK DNFFQLGGHS LLATNLIFSL NDIFNIRIPL KELFENPTIL GNSKFIQSQL
GIVHTQKKDT DNLEKDIQLP ENFEIIKEKT REDLQHILIT GATGFFGSFL VHRLLNDTSA
TVYCLVRAKD QQHARERLVK SLQDYKIYDP AYEQRIVAIC GDLELPNLGM NEADYNLYSK
TIDTVIHNGA KVNFFEPYKN LKKTNVKGTL NIIQFAALHR LKPIHFISTL YVYEPSQDPH
SERLIDEDQP LGGYKNLPMG YTQSKWVSEK ILELARNKGL PVNIYRLGRI SGHSKTGACQ
QKDFIWSLVK GCIETGVYPN QNLTFELTPV DYLTDAVVQI IKSNELNTNY HLFNLKKISL
QEIVQSISDS YDLKSTDMKQ WINDISSAKS SARHFAQLLS DGTFNGGSLH FKNKHTSQHV
PYFKNGIHIN EAMLRAQKNY FIETQYFPVK
//