ID G5JUF7_9STRE Unreviewed; 2164 AA.
AC G5JUF7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=AMP-binding enzyme {ECO:0000313|EMBL:EHJ52313.1};
GN ORFNames=STRMA_0780 {ECO:0000313|EMBL:EHJ52313.1};
OS Streptococcus macacae NCTC 11558.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=764298 {ECO:0000313|EMBL:EHJ52313.1, ECO:0000313|Proteomes:UP000003573};
RN [1] {ECO:0000313|EMBL:EHJ52313.1, ECO:0000313|Proteomes:UP000003573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 11558 {ECO:0000313|EMBL:EHJ52313.1,
RC ECO:0000313|Proteomes:UP000003573};
RX PubMed=24625962; DOI=10.1093/gbe/evu048;
RA Richards V.P., Palmer S.R., Pavinski Bitar P.D., Qin X., Weinstock G.M.,
RA Highlander S.K., Town C.D., Burne R.A., Stanhope M.J.;
RT "Phylogenomics and the dynamic genome evolution of the genus
RT Streptococcus.";
RL Genome Biol. Evol. 6:741-753(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHJ52313.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEUW02000001; EHJ52313.1; -; Genomic_DNA.
DR RefSeq; WP_003080184.1; NZ_UHFV01000002.1.
DR STRING; 764298.STRMA_0780; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 2203144at2; -.
DR Proteomes; UP000003573; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020459; AMP-binding.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR PRINTS; PR00154; AMPBINDING.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 993..1068
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2057..2132
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2164 AA; 247862 MW; A720F2FA9601CED4 CRC64;
MKSDEQNKMN DQNKKSKAES LLAKRLGKQK KQREIRFESN FLQEYGVSSI QKNMLENEEM
DDKVSAYNLV SAVDVSGRLD LEALRQAFNC LIQSNSSLKT KFTATNDGYK QIIEEVSFAD
LDYIDLSEKS NGESELKEII LSKSLQKMPL ESSPLLQLSV IQLKSDQFVI VLVAHHTVMD
GWSFGLAVHQ LQDYYNLYKQ NGTIAPASEK YNTIDYLIWK NRNKKDSKSY WIKELTNTNI
LRLESDFERG VQSSYRGKRL YFTLDKQLTE LMKQYEKVHH ITVANIILSA YQILLHKYTG
QNDFVIGTAV ADRENIAVRN MIGCLINTLG VRTIINDDLE IKDYLEHTQK HFYEIMKHKD
IDLYECLEEL EYEQDNRFST LFQAMYNYEN TPKAKMNFKD LDIGFRNVEA GSALFDLTLS
IFDTDDGLNG FIEYKADLFK PSRIEQLLQC FIHILNTIVK KPEIAVKDIS LLSPQQESEL
LEINTKKEIK ETLFTDKFKK IVSKYGKNTA LSFEKQSVTY EQLDIASDII AQQLLNQAAP
KSLIGVFMNK SIDAIVAMLS ILKAGMVYVP IDTGYPIERI RYITKDAGIY HLLTHKQVSR
NIDWQSLGIK NINDIEEMQA NLTLTPPSQL SKVSLDAEDT AYIIYTSGST GKPKGVMVAH
RGLCNIVEEQ NNLFAVDDKS KVLQFASFCF DASVFEIVMA LGNGAELHIV DKDQVLGDHL
TQFIKDKAIT HICVTPSVLS LASSETLDKL ETIIVAGEAC PSELVNMWGK HHQFFNAYGP
TEATIWTTTK RCLPNSKVTI GKPLNNVEVF VLDEQLNMLP KGNIGELYIG GIGVCKGYLH
REELNHQKFV QKTFSDGHES TLYATGDIVR WDENGELEFM GRKDNQVKLR GFRIEIDEIR
SKILEYPDTQ DAVIGITNKD GMDLLYAVIK NKLDINDSKA FKDFLKGKLP YYMIPSLINF
VDEIPLTWNG KVDSKQIEEN LIFYTDTKRD LKEPTTKIQR ELLTIWQTIL ATEAISTDDN
FFELGGHSLI ATKLINAINQ QFQIDLTANM IFNYPTILEM EAYLEKLDRV SDSLPIKKVE
RQKELLLSPQ QKQLWLMEQM VPQNGNYNIV TPIRLKGNLN IKLLEKSFNQ LIKNHEILRV
NFHDKEGVPY QIINEKANIR LQHHYLMNFD LSQAESIANT ILAFDEKRPF NLSSELLIRS
SLIHLNEEEY ILIIVMHHII SDGWSMELLI DELSEIYNKL LKRQEDSMLP KQHLSLQYLD
YTYWLDQEKN REKKQKEFWK NTLSSDMPAL SFPADYKRPA IQTHNGYTVE QILDEELSHQ
LKKFCQDNNI TTFMFMLTIF SILLHKLSGE EDLPIGVPVA GRTKKEMENM IGFFVNTVVM
RCKLNTNLTI LDYLEVIRNT TLLAFENQDV PFDDIVQMLS PSRDTSRSPL VQVMLNVQNP
EGIKCHMDGL EAAPYPLTQE ITKFDATLYV EEYFGKMKFR LVYNSDLYKE ESMQEYLRQL
NTVMVAVLQN KKTKIKDISI QSQHFSQLLK AKETLADSSL IRFNSSLCID EVVSRNAAKY
PERLAISDES GSLTYLQLEE KSEKLAAVLS NQGLGKGSIF VIYGDRNMKL IISMLAILKI
GGIFCIFDPE YPEIRLKKQL ESIKADGAIV INHEELKNAD FLNKNLKLYN SYDELMHISK
EQPLVRQAVT KDIKDTAYIL FTSGTTGKPN CVSTSHEPIN HFIKWFVKHY QLDESSVFGL
FAGLSHDPLI RDIFTPLFIG GRLAIQNQKS RYDIEDTGQW INDQGINEIN ITPSLFLMLS
EGDNISFPKV KHYFFGGELL TAAPVQRAQT ISPMAQCVNF YGTTETPQVM GFYDIPEDFD
LENNVIPIGS GIDAVRLSLL NDAGLETGVG ELGEIYVETS YLSEGYVNNE ALNLEKFFNS
QNQTGWRRYK TGDVGRYQYD GSIVIEGRKD TQINVRGYRV EAEEIELSLA KHDNIRRSVV
YPVSVKGRKQ LIAYLEVIDQ KAFTTSDIRD FLRTYIPENI IPERFVLVSQ IPLTPNGKVD
YRKLPKEFTK QTPAITQPKD IIERKIKQIW LDVLNIDDIS TDENFFDAGG HSLLLSRIKV
LLEQKLNVNL KLMDLFSYPT IKLISDYIKQ KTEGVKHNIK GSHIADNTSN RINKQRQSFG
NFKR
//