ID G5JY18_9STRE Unreviewed; 395 AA.
AC G5JY18;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
GN ORFNames=STRMA_0065 {ECO:0000313|EMBL:EHJ52475.1};
OS Streptococcus macacae NCTC 11558.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=764298 {ECO:0000313|EMBL:EHJ52475.1, ECO:0000313|Proteomes:UP000003573};
RN [1] {ECO:0000313|EMBL:EHJ52475.1, ECO:0000313|Proteomes:UP000003573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 11558 {ECO:0000313|EMBL:EHJ52475.1,
RC ECO:0000313|Proteomes:UP000003573};
RX PubMed=24625962; DOI=10.1093/gbe/evu048;
RA Richards V.P., Palmer S.R., Pavinski Bitar P.D., Qin X., Weinstock G.M.,
RA Highlander S.K., Town C.D., Burne R.A., Stanhope M.J.;
RT "Phylogenomics and the dynamic genome evolution of the genus
RT Streptococcus.";
RL Genome Biol. Evol. 6:741-753(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHJ52475.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEUW02000001; EHJ52475.1; -; Genomic_DNA.
DR AlphaFoldDB; G5JY18; -.
DR STRING; 764298.STRMA_0065; -.
DR eggNOG; COG0116; Bacteria.
DR Proteomes; UP000003573; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR47313; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K/L; 1.
DR PANTHER; PTHR47313:SF1; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE K_L; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 57..171
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 395 AA; 44691 MW; AF2033623E488AC2 CRC64;
MLAFIVCLVR TFMKKMFDLI ATTAAGVEAV VGKEIKGLGI DCRLENGRVL FQGDVEIIAK
TNLWLRAADR IKILVGEFSA KTFEELFQGV LALDWGNYLP LGCQFPIAKA KSVKSKLHNE
PSIQAITKKA IVKKLQKHFH RPQNVPLLEN GPEFKIEVSI LKDRARIMLD TTGPSLFKRG
YRIDKGGAPL KENMAAAIIL LSNWFPDKPF VDPTCGSGTF CIEAAMIGKN IAPGTNRHFA
FEKWPWVDQA VMNKVRSEAK SQVTDLELDI LGFDIDGRVI EIAKNNVRAA GLEDVIKLKQ
MRFQDFKTDK INGVIISNPP YGERLLDDKA IDILYNEMGK AFAPLKTWSQ FILTSDETFE
KKFNRQADKK RKLYNGTLRV DLYQFYGQRV KREDK
//
