ID G5K2X9_9STRE Unreviewed; 248 AA.
AC G5K2X9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein {ECO:0000313|EMBL:EHI69704.1};
GN ORFNames=STRIC_1147 {ECO:0000313|EMBL:EHI69704.1};
OS Streptococcus ictaluri 707-05.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=764299 {ECO:0000313|EMBL:EHI69704.1, ECO:0000313|Proteomes:UP000003330};
RN [1] {ECO:0000313|EMBL:EHI69704.1, ECO:0000313|Proteomes:UP000003330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=707-05 {ECO:0000313|EMBL:EHI69704.1,
RC ECO:0000313|Proteomes:UP000003330};
RX PubMed=24625962; DOI=10.1093/gbe/evu048;
RA Richards V.P., Palmer S.R., Pavinski Bitar P.D., Qin X., Weinstock G.M.,
RA Highlander S.K., Town C.D., Burne R.A., Stanhope M.J.;
RT "Phylogenomics and the dynamic genome evolution of the genus
RT Streptococcus.";
RL Genome Biol. Evol. 6:741-753(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI69704.1}.
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DR EMBL; AEUX02000006; EHI69704.1; -; Genomic_DNA.
DR AlphaFoldDB; G5K2X9; -.
DR STRING; 764299.STRIC_1147; -.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000003330; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000003330}.
FT DOMAIN 32..209
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT SITE 164
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 248 AA; 28326 MW; 6C88E6952F6EA9C4 CRC64;
MKTFSYVLFG NYIKKRYDKT IKKEWGSYMR RVTILGSGMM GKQIATFLIN NNMTVDLVKV
TDTKDWQKDL AKLEAYVTKR LFKLEYINRL QVKHLEDVLT DGITSDLVIE AVVEDLVAKQ
VLFGRVLAVI APETIIATNT STLSITRIAE GFKASEKNRF LGLHFFAPVR HMKLVEVIPH
ELLSQVYVKK INHFISNQLG KEAIVVKDVL GFLANRIGFF ANHDVMRLSE HYGMAPELVD
YLSCHALK
//
