ID G5KGR0_9STRE Unreviewed; 851 AA.
AC G5KGR0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EHJ57529.1};
GN ORFNames=STRUR_0082 {ECO:0000313|EMBL:EHJ57529.1};
OS Streptococcus urinalis 2285-97.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=764291 {ECO:0000313|EMBL:EHJ57529.1, ECO:0000313|Proteomes:UP000005388};
RN [1] {ECO:0000313|EMBL:EHJ57529.1, ECO:0000313|Proteomes:UP000005388}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2285-97 {ECO:0000313|EMBL:EHJ57529.1};
RX PubMed=24625962; DOI=10.1093/gbe/evu048;
RA Richards V.P., Palmer S.R., Pavinski Bitar P.D., Qin X., Weinstock G.M.,
RA Highlander S.K., Town C.D., Burne R.A., Stanhope M.J.;
RT "Phylogenomics and the dynamic genome evolution of the genus
RT Streptococcus.";
RL Genome Biol. Evol. 6:741-753(2014).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHJ57529.1}.
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DR EMBL; AEUZ02000001; EHJ57529.1; -; Genomic_DNA.
DR RefSeq; WP_006740233.1; NZ_AEUZ02000001.1.
DR AlphaFoldDB; G5KGR0; -.
DR STRING; 764291.STRUR_0082; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000005388; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000005388}.
FT DOMAIN 676..692
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 602..609
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 851 AA; 96405 MW; 92001CAD2ACF400D CRC64;
MTKDKISPGM QQYLDIKKDY PDAFLLFRMG DFYELFYEDA VKAAQILEIS LTSRNKNAEN
PIPMAGVPYH SAQQYIDVLI ELGYKVAIAE QMEDPKKAVG VVKREVVQVI TPGTVVDSSK
PDQANNFLVA IDKIDTNFGL AYMDLSTGEF FTTVPSDFTT VTSEILNLKA REVLVGYELL
PEEEAILSNQ MNLLLSYESD IYEDQKLIPN DLSIVEKTIT GKLLQYVFKT QKRELSHLQA
VQHYEVKDYL QMSYTTKSSL DLLENSRTGK KHGSLYWYLD ETKTAMGLRL LRTWIDRPLV
TPEKIVERQE IITAFLEQFM ERSDLTESLK GVYDIERLAS RVSFGKANPK DLIQLGNTLS
QIPLIKSILA TFDNLYIDKL VNQIDALPEL EGLINQSIDP QAPATIQEGN IIRTGFDDKL
DSYRQVLKEG TRWIAEIETK ERQSSGISNL KIDYNKKDGY YFHVTNSHID LVPDYFFRKA
TLKNSERYGT AELAKIEGQM LEAREESANL EYTIFMSVRS QVEKFIIKLQ HLAKTIASVD
VLQSLAVVAE KNHLTKPQFN DKQEISIIDG KHPVVEKVMG TQEYIPNDIC FDRETNIQLI
TGPNMSGKST YMRQLALTVV MAQMGSYVAA TEANLPIFDA IFTRIGAADD LISGQSTFMV
EMMEANQAIR RSTKQSLILF DELGRGTATY DGMSLAQAII EHIHHYVGAK TLFATHYHEL
TALEKELPHL VNVHVSTIEN NGEVTFLHKI AEGPADKSYG IHVAKIAGLP DDLLNRANKV
LNHYETQSKN QKISDNHDES ESQFVNEQLS LFITNEDDNQ EVISLLKEVD VMNLTPLQAM
NLIFEMKDKL K
//
