ID   G5ZYK7_9PROT            Unreviewed;       945 AA.
AC   G5ZYK7;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Anaerobic dehydrogenase, typically selenocysteine-containing {ECO:0000313|EMBL:EHI48979.1};
GN   ORFNames=HIMB100_00011120 {ECO:0000313|EMBL:EHI48979.1};
OS   SAR116 cluster alpha proteobacterium HIMB100.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; SAR116 cluster.
OX   NCBI_TaxID=909943 {ECO:0000313|EMBL:EHI48979.1, ECO:0000313|Proteomes:UP000004261};
RN   [1] {ECO:0000313|EMBL:EHI48979.1, ECO:0000313|Proteomes:UP000004261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=strain HIMB100 {ECO:0000313|Proteomes:UP000004261};
RX   PubMed=22675578; DOI=10.4056/sigs.1854551;
RA   Grote J., Bayindirli C., Bergauer K., Carpintero de Moraes P., Chen H.,
RA   D'Ambrosio L., Edwards B., Fernandez-Gomez B., Hamisi M., Logares R.,
RA   Nguyen D., Rii Y.M., Saeck E., Schutte C., Widner B., Church M.J.,
RA   Steward G.F., Karl D.M., Delong E.F., Eppley J.M., Schuster S.C.,
RA   Kyrpides N.C., Rappe M.S.;
RT   "Draft genome sequence of strain HIMB100, a cultured representative of the
RT   SAR116 clade of marine Alphaproteobacteria.";
RL   Stand. Genomic Sci. 5:269-278(2011).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHI48979.1}.
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DR   EMBL; AFXB01000008; EHI48979.1; -; Genomic_DNA.
DR   AlphaFoldDB; G5ZYK7; -.
DR   STRING; 909943.HIMB100_00011120; -.
DR   PATRIC; fig|909943.3.peg.1133; -.
DR   eggNOG; COG0243; Bacteria.
DR   OrthoDB; 9810782at2; -.
DR   Proteomes; UP000004261; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02783; MopB_CT_2; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 3.30.200.210; -; 1.
DR   Gene3D; 3.40.50.740; -; 1.
DR   Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   PANTHER; PTHR43598:SF5; DMSO REDUCTASE CHAIN A; 1.
DR   PANTHER; PTHR43598; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B; 1.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SUPFAM; SSF50692; ADC-like; 1.
DR   SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004261}.
FT   DOMAIN          14..70
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51669"
FT   REGION          914..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  104390 MW;  B942073ABF7903A8 CRC64;
     MSQPQLNPSP PVSDEVRKTT CYMCACRCGI NVHLRDGKVR YIEGNRDHPV NQGVLCAKGS
     AGIMQHYAPS RLTSPMRRVG ERGEGKFEPI SWEEAMAMAT DWLDPIRKSD PSRLAFFTGR
     DQSQGLTGWW AQQFGTHNFA AHGGFCSVNM AAAGIYTMGG AFWEFGSPDW ERTKLFMIFG
     VAEDHDSNPI KMGLSRLKAR GAKVVAVNPV RTGYNAIADE WVGITPGTDG LFVLALIHEL
     FCAGKIDLDY LIRYTNAPWL VIDSPEHEQH GLFLRDKDGV PQVLDRKTGK AVSKDKKAVK
     PDLKGEVVTK DGLRAVPVFM KMAEAYMDDG YAPEAVAEAT GVSAAQIKAI AAELARVAFE
     EEIVIDQPWT DFKGEQHDKM IGRPVSMHAM RGISAHSNGF QTCRAIHLLQ ILLGSIECPG
     GFRFKPPYPK PSTAHPAPGR ITEAGKPASG PPLGYIHGPE DLLIDETGAP LRIDKAYSWD
     APFSAHGLMH MVISNAYAGD PYPVDVLFMY MANMSWNSSM NSGGVMEMLK AKREDGKYVI
     PKIIYSDAYS SEMVAFADLI LPDTTYLERH DCISLLDRPI CETDAVADSI RWPVVEPDRD
     VRGFQSVLLD LGARLGLPGM TNEDGSPKFA DYADYMVNHQ RKPGIGPLAG FRGEEGDKMG
     RGEPNPDQIE RYIENGGFWV EEIPEGAKFY KHANTAYQDW AVEMGFFDAP QPVTFQLWLE
     PLAKFQLAAG GHGPHTAPEH VKDRIKAHFT PLPHWYAPYE GAALGTDEAD YPYHAITQRP
     AAMYHSWGSQ NAWLRQIHTH NPLYVPGPVC DEAGLTDGDW AWVSSHHGRI KVQVKRMEAV
     NSRTLWTWNA IGKRRGAWAL SPDAPEAKKG FLLNHLIHEL LPGSEDGLRM SNSDPITGQA
     AWYDLRVKIE KAEEGAGVTE PVTGTQAGPN SPPEGSLRYG QEWSK
//