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Database: UniProt
Entry: G6XMF2_9PROT
LinkDB: G6XMF2_9PROT
Original site: G6XMF2_9PROT 
ID   G6XMF2_9PROT            Unreviewed;       625 AA.
AC   G6XMF2;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=GMO_26700 {ECO:0000313|EMBL:EHH67050.1};
OS   Gluconobacter morbifer G707.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=1088869 {ECO:0000313|EMBL:EHH67050.1, ECO:0000313|Proteomes:UP000004949};
RN   [1] {ECO:0000313|EMBL:EHH67050.1, ECO:0000313|Proteomes:UP000004949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G707 {ECO:0000313|EMBL:EHH67050.1,
RC   ECO:0000313|Proteomes:UP000004949};
RA   Lee W.-J., Kim E.-K.;
RT   "Genome sequence of Gluconobacter morbifer G707, isolated from Drosophila
RT   gut.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHH67050.1}.
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DR   EMBL; AGQV01000013; EHH67050.1; -; Genomic_DNA.
DR   RefSeq; WP_008852811.1; NZ_AGQV01000013.1.
DR   AlphaFoldDB; G6XMF2; -.
DR   STRING; 1088869.GMO_26700; -.
DR   PATRIC; fig|1088869.3.peg.2663; -.
DR   eggNOG; COG0323; Bacteria.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000004949; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000004949}.
FT   DOMAIN          214..331
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          432..581
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          332..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  67564 MW;  285C4198256436BB CRC64;
     MSETSSPRSS IRRLSGHVID LIAAGEVIER PAAALKELVE NAIDAGATRI SVALRGGGTD
     RIDVTDNGCG MTPAELELAV ERHCTSKLHD EHLVQIRTLG FRGEALPSIG ASARLSITSR
     TPDADTAWCL RVDGGVITPP QPASGPAGTR IVVTDLFFAT PARRKFLKSA RVEGGHAESV
     MRRLALSAPH CAMRVTMDDR LLFDLPEQSP IARTAAILDT TPEMLLLLDE QRGAVRLSGF
     ACGPARTRAT GAGQFILVNN RPVTDPMLRT AIRVAYRPVI ERGRFPVMAL HLKVPLERLD
     VNVHPAKTEL RFADEAEVRS LVIGGLGRAL GHGSSRGGGL HASFGSRPRP SIAYPPRPDR
     AALEERLPAF TAEQDEQDGT PLPPASSAIF VSSDVSLPRR EGFAETDQEF APAARVPRQP
     EALDAAFPLG AAIAQVFDTY IIAVAPDGDL VLVDQHAAHE RLTHERLRAQ YASGHLRSQA
     LLLPEVVDLP RREAEALLAC TEDLSKLGIE LESFGPGSVL LRSVPALLGT KDVQGLLRDI
     ADELADDPAL DAGSTDSFSH RLDAVIARMA CHGSIRAGRR LKPEEMDALL REMERTPRAN
     TCSHGRPTWL KLTRNELERL FGRVK
//
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