ID G7CCN5_MYCT3 Unreviewed; 1304 AA.
AC G7CCN5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:EHI14242.1};
GN ORFNames=KEK_03657 {ECO:0000313|EMBL:EHI14242.1};
OS Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP
OS 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1078020 {ECO:0000313|EMBL:EHI14242.1, ECO:0000313|Proteomes:UP000004915};
RN [1] {ECO:0000313|EMBL:EHI14242.1, ECO:0000313|Proteomes:UP000004915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 /
RC 316 {ECO:0000313|Proteomes:UP000004915};
RG Tuberculosis Structural Genomics Consortium;
RA Ioerger T.R.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI14242.1}.
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DR EMBL; AGVE01000019; EHI14242.1; -; Genomic_DNA.
DR PATRIC; fig|1078020.3.peg.725; -.
DR eggNOG; COG1643; Bacteria.
DR Proteomes; UP000004915; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EHI14242.1};
KW Hydrolase {ECO:0000313|EMBL:EHI14242.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000004915}.
FT DOMAIN 73..236
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 278..446
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1304 AA; 146040 MW; F45096D8E47069A7 CRC64;
MRALRARLDG LTHRDAARLG RRLRQVRGAK PEQLQRIAEQ IAAGEALVAA RAAAVPEISY
PDLPVSERRH EIAEAIANHQ VVVVAGETGS GKTTQLPKIC LELGRGIRGT IGHTQPRRLA
ARTVAQRIAD ELGTPLGEAV GYTVRFTDQA GDRTLVKLMT DGILLAEIQR DRRLLRYDTI
IIDEAHERSL NIDFLLGYLK GLLPRRPDLK VIITSATIEP RRFAKHFDAP VVEVSGRTYP
VEIRYRPLEV PAGTDTADDP DDPDHEIVRT EIRDQTEAII DAVRELDAEP PGDVLVFLSG
EREIRDTAEA LRGTLDPDVE VLPLYARLPT AEQQKVFTPH RLRRRIVLAT NVAETSLTVP
GIRYVVDPGT ARISRYSRRT KVQRLPIEPI SQASAAQRAG RSGRVAPGVC IRLYSEEDFE
SRPEFTEPEI LRTNLAAVIL QMAALGFGAV EDFPFLDPPD QRSIRDGVAL LRELGAFDER
GEITDVGRRL AQLPVDPRLG RMVLQAETEG CVREVLVLAA ALSIPDPRER PLDKEDAARA
KHARFADEHS DFMSYLNLWR YLTEQRKERS GNSFRRMCRE EFLHYLRIRE WQDLVGQLRS
IARDIGIRES PDPEPAAPDR IHAALLAGLL SHVGMRDDQR DRKSRDRARD RGPREYLGAR
NTRFVLAPGS VLTRQPPRWV VVAELVETSR LYGRIAARID PQTVERVGAH LVQRGYSEPH
WDAQRGAAMA YERVTLYGLP VVPRRRVGYA TVEPEVAREL FIRHALVEGD WHTRHRFFHD
NARLRDELAA LEDRARRRDL LVGDDEIYEF YAARIPDTVV SARHFDAWWK KQRHRTPDLL
TMRREDLLRT DDADAEQPDT WQSGDVELPL SYRFEPGAAD DGVTVHVPVH VLARLGGDDF
AWQVPALREE LITELIRSLP KDLRRNFVPA PDTARALLTT LQPGDEPLLE AVQRELHRRT
GILVPIDAFD LDRLPAHLRV TFAVEGPDGT EVARGKDLAA LQERLAGTTR RAVADAVGAD
LERTGLRDWP EDLEELPRTV ERRAVRGYPA LVDTGPAVDL RVLPTEAEQS AAMRPGLRRL
LRLTVPSPVK AVERALDPRA RLVLGNNPHG SPTALLEDCA DAAVDVLAQT PVWTRAEFLA
VRDRVAAKLA ATTQNVVGRV QHVLAAAQRV QLALPDPPPP TQADAVADIR DQLGRLLPAG
FVTASGAGRL ADLTRYLTAI ERRLERLPHA VAADRDRMAR VHAVQEAYEE LVAAVSPARA
ARPDIAEIRW MIEELRVSLW AQQLGTARPV SEQRIYRAID GVQL
//
