ID G7CEW1_MYCT3 Unreviewed; 386 AA.
AC G7CEW1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EHI13040.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:EHI13040.1};
GN ORFNames=KEK_07652 {ECO:0000313|EMBL:EHI13040.1};
OS Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP
OS 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1078020 {ECO:0000313|EMBL:EHI13040.1, ECO:0000313|Proteomes:UP000004915};
RN [1] {ECO:0000313|EMBL:EHI13040.1, ECO:0000313|Proteomes:UP000004915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 /
RC 316 {ECO:0000313|Proteomes:UP000004915};
RG Tuberculosis Structural Genomics Consortium;
RA Ioerger T.R.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHI13040.1}.
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DR EMBL; AGVE01000042; EHI13040.1; -; Genomic_DNA.
DR RefSeq; WP_003925028.1; NZ_AGVE01000042.1.
DR AlphaFoldDB; G7CEW1; -.
DR PATRIC; fig|1078020.3.peg.1505; -.
DR eggNOG; COG0183; Bacteria.
DR Proteomes; UP000004915; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:EHI13040.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004915};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EHI13040.1}.
FT DOMAIN 5..255
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 263..385
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 342
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 372
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 386 AA; 41278 MW; ED9D1EAE742A7FBB CRC64;
MSEAYVIDAV RTPTGKRNGS LAALHPIDLG VHAFRGIFDR NDVDPAAVDD VVVGCVDAIG
GQAGNIGRLM WLAAGYPEEV PGVTVDRQCG SSQQAISFGA QAIMSGTADI ILAGGVQNMS
QIPISSAMIV GKEFGFTSPT NESKYWLHRY GDQEISQFRG AEMIAERWEI SREDMERYAL
TSHERALAAI RAGRFDNEII GVPVDGGEFR IDETPRETSL EKMAALPTLT EGGRMTAAVA
SQISDGASAV LLASEKAVKE HKLKPRARIH HISARGDDPV LMLTGPIPAT RYALEKTGLS
MDDIDVVEIN EAFAPVVIAW EKELKVDHAK VNPNGGAIAL GHPLGATGAK LFATMLNELE
RTGGRYGLQT MCEGGGTANV TIIERL
//
