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Database: UniProt
Entry: G7CNK2_MYCT3
LinkDB: G7CNK2_MYCT3
Original site: G7CNK2_MYCT3 
ID   G7CNK2_MYCT3            Unreviewed;       351 AA.
AC   G7CNK2;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   16-OCT-2019, entry version 36.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=KEK_23001 {ECO:0000313|EMBL:EHI10406.1};
OS   Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 /
OS   CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium
OS   thermoresistibile).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1078020 {ECO:0000313|EMBL:EHI10406.1, ECO:0000313|Proteomes:UP000004915};
RN   [1] {ECO:0000313|EMBL:EHI10406.1, ECO:0000313|Proteomes:UP000004915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 /
RC   316 {ECO:0000313|Proteomes:UP000004915};
RG   Tuberculosis Structural Genomics Consortium;
RA   Ioerger T.R.;
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EHI10406.1}.
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DR   EMBL; AGVE01000056; EHI10406.1; -; Genomic_DNA.
DR   RefSeq; WP_003928058.1; NZ_AGVE01000056.1.
DR   STRING; 1078020.KEK_23001; -.
DR   EnsemblBacteria; EHI10406; EHI10406; KEK_23001.
DR   PATRIC; fig|1078020.3.peg.4545; -.
DR   OMA; YDINTGL; -.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000004915; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004915};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004915};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:EHI10406.1}.
FT   DOMAIN       51    344       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   351 AA;  37684 MW;  C3A671CC5BB09742 CRC64;
     MNSAQITTAP KTSDRRIRGF LEIPSPHDVL SEFPLGARRA ELVARDRDEI ADILAGRDDR
     LLAVVGPCSV HDPAAALDYA SRLVKVAEEL RDDLKVVMRV YFEKPRTTVG WKGLINDPAM
     DGTFDVARGL RIARQLLLDV IDIGLPVGCE FLEPNSPQYI ADAVAWGAIG ARTTESQVHR
     QLASGLSMPV GFKNGTDGNI QVAVDGVKAA AAPHVFFGMD DLGRGALVST EGNEDCHVIL
     RGGSRGPNWD AESVRQTADM LTAAGLPGRV VVDCSHANSG KDHVRQAEVA VEVAKLVRAG
     LPISGVMLES FLVAGAQSPD TKPLTYGQSV TDKCMDWATT DSVLRELAKR R
//
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