ID   G7DT24_MIXOS            Unreviewed;       727 AA.
AC   G7DT24;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Xaa-Pro aminopeptidase P {ECO:0008006|Google:ProtNLM};
GN   Name=Mo00549 {ECO:0000313|EMBL:GAA93903.1};
GN   ORFNames=E5Q_00549 {ECO:0000313|EMBL:GAA93903.1};
OS   Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC   Mixiales; Mixiaceae; Mixia.
OX   NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA93903.1, ECO:0000313|Proteomes:UP000009131};
RN   [1] {ECO:0000313|Proteomes:UP000009131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC   {ECO:0000313|Proteomes:UP000009131};
RX   PubMed=21478649; DOI=10.2323/jgam.57.63;
RA   Nishida H., Nagatsuka Y., Sugiyama J.;
RT   "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL   J. Gen. Appl. Microbiol. 57:63-67(2011).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAA93903.1}.
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DR   EMBL; BABT02000025; GAA93903.1; -; Genomic_DNA.
DR   RefSeq; XP_014571344.1; XM_014715858.1.
DR   AlphaFoldDB; G7DT24; -.
DR   STRING; 764103.G7DT24; -.
DR   MEROPS; M24.009; -.
DR   GeneID; 26266693; -.
DR   eggNOG; KOG2413; Eukaryota.
DR   HOGENOM; CLU_011781_2_4_1; -.
DR   InParanoid; G7DT24; -.
DR   OMA; EPGMILS; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000009131; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763:SF21; X-PRO AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009131}.
FT   DOMAIN          132..264
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          436..652
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          666..727
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
FT   REGION          33..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  80110 MW;  ADE6BE43F63B487C CRC64;
     MLRLGTRLRN CRSSTQASPL AFVLQAEHRV VRKPWQRSRS TGEPGSDSVS SSHYTTTEQL
     EALPASDFLQ KDGRDRSHIR TEAELLQSVP RFRTVTRQEH RARIESLQRP TAPIDTMGAV
     VKPGGPVKTN DRIKALRSLL AQHALTAYVV PAEDAHASEY SCAADKRREF ISGFSGSAGT
     VVVTEKEACL FTDGRYFLQA SQQLDTDWTL MRSGEPDVPT WQEYLGKLPP NAQVGIDPTL
     ISAADAKTIS ASLTSKSSQL VSLAKNLVDE LWTDRPQRPE NPLTVIPDSL AGRSAAEKIA
     NMRKDLEKRK ADALVVSMLD EVAWLFNLRG SDIPYNPVFF AYALVTPSEV SLFVDADKVP
     EEVKHELPTE VSIRPYDEIF SRLEGLASSL REGAKVVIGN KTSLALATAA GTQNVDIVQS
     PIAEAKAIKN EVELEGFRES HIRDGAALVA YFAWLEEQLA SGAELKESAA ADKLEDLRSK
     LPRYKGLSFT TISSTGPNAA IIHYSPDPES CATIDKDQIY LCDSGAQFED GTTDVTRTLH
     FGKATDEERH AFTRVLQGHI SIDSAVFPKG TTGYVLDAFA RRALWADGLD YRHGTGHGVG
     HALNVHEGPA GIGTRLAYNE TALKAGMVLS NEPGFYKDGS FGIRIENLVI VKDVKARYNF
     GNKGSLGFER ITMCPIQTSL IDKSLLTPQE VQWVNEYHKE VLEKLSPLLK DSDPRAYKWL
     QRETKPF
//