ID G7DXR6_MIXOS Unreviewed; 768 AA.
AC G7DXR6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN Name=Mo02030 {ECO:0000313|EMBL:GAA95376.1};
GN ORFNames=E5Q_02030 {ECO:0000313|EMBL:GAA95376.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA95376.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA95376.1}.
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DR EMBL; BABT02000061; GAA95376.1; -; Genomic_DNA.
DR RefSeq; XP_014569775.1; XM_014714289.1.
DR AlphaFoldDB; G7DXR6; -.
DR STRING; 764103.G7DXR6; -.
DR GeneID; 26268113; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_3_2_1; -.
DR InParanoid; G7DXR6; -.
DR OMA; LEYKFLH; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 467..547
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 664..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 85967 MW; 50A8A01B13886377 CRC64;
MATTDPGQDW EAYQSSISQV IKPATVAARQ LKDVAYCRTV SDRFASDAHS ASRHVLELTN
KLLGLVRSSL HEESSDELQD IDDVTDRFER SVVHVVDHLL EAADAQLDLL SGRHKPKPLQ
TTSQTTDQRL PASLMNAKDL EKPQIHFSRP VNNARGQLFR PLLTSKPHAL VAYDPATYDT
SESNPYSHEI EALPLLASPD NLPSEISKKA IDSFSSTPFT YVDTAEQLDR LLQELKRPDH
AEIAIDLEHH DFRSYVGFVC LMQISTRSHD WIVDTLVSEV RDRLESLNEV FADPAKVKVM
HGAQSDVIWL QRDFGLYIVN LFDTYHATVV LSYGQRSLAS LLTKYTHFVP DKRYQLADWR
LRPLPQEMID YARSDTHYLL NIYDHLRRAL IATKLDPTPE HALDGSETLL QRVDRRSRIV
ASQAYHGSDY DYESGLGANG WRGLVRVMNK GAEYRVNLAK GETSSGRGPE FAAFRAAHSW
RDQLARELDE SPRYIMSHHL VCRLGTVRPT RPADVLACCS VASQTVLRRA SELAQVIKAA
LDTPQATEVS SRSTLESISA LVASPSEPRI RQVLPEVWPP MPVPMNDGAS RFYTTLRTQD
STPAQKAVAN IQRTISEQLF AMHSTAILVP VSSGESRVEE AIAASAASSS DDSDDVLHIS
ETVRQEKTNA CQKRARPDAP ATPKGEIRPK QSRAQSKKEH IKVEPYDYSK SKSVLEGYKE
EAFDVQAMRA AKKSKLDQAS IETPAFRRQP KALTLDKQSG NKNVTFQK
//
