ID G7DZ07_MIXOS Unreviewed; 1299 AA.
AC G7DZ07;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN Name=Mo02474 {ECO:0000313|EMBL:GAA95817.1};
GN ORFNames=E5Q_02474 {ECO:0000313|EMBL:GAA95817.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA95817.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA95817.1}.
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DR EMBL; BABT02000067; GAA95817.1; -; Genomic_DNA.
DR STRING; 764103.G7DZ07; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_0_0_1; -.
DR InParanoid; G7DZ07; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 54..134
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 845..969
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1039..1269
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 143141 MW; 9826E91756C85AF8 CRC64;
MSLMTSRHRD LPSREERGQV NDADEDTQSV SRAAQRSRAS TTRAVDIFQD AMDVQPEWVE
ALHAYTPSDA MLARPQDTSD GEPSAQKACL AFNPGDLIRV IHKDPSGWWD GCIKQERALV
RGWFPSNYVR EIQIESLRDG AGQAAAADDT VVASSSADTL VISSSHAAPT LEERRPSLRL
AQSYDHSRVN SVREGRPVLT SAHSSPARSN APSPASQVLD AKRATGAAMI GSAALSRART
TDAPEFTDML RATRHAIGLL RKAVSARDLS HYQPSTACLI SAIRAVLCAT GCLDRDSEQL
ACFPQLAIQR KLVLSALARL VNQARKASTL DENVAPGSEA PIGPTALVMI DMAEGVMAQI
EQFLASLFEC GYDPVKPPDS PRMREPSSDT VTGPVQEPRG ELARPTSRLL PRASFLSGAR
KSSNPKKPEL HKVRSLGDLR NRRRSAKDSA PVPMPGSPRL EDSMPIRPLL QRGSTAMRSF
MQAAEQQPTV SADAQSGWHA PLRLHTAAEI KSIMSQLHAQ LLRTVAAFVS QAQVHTSTSH
ATSFLYLLDL AEEVIGTVRE ILDIIDVMRS SDSDRAIEDA HLLDISSNAV SRASIDLAQA
TEISLKRNAT ASDHRHLLHC ATLVLQTAAE SSSAVTIYLS HRLAEDGYAL SEPASSSIVR
RNGSPDELAF ALARLANQRQ DLQTSEPEDF ARARSSYERI ELLAAAQHSA KPDTHTSAGG
RPQLMTDRSS IYGVQYQGGE SMHRELSSRT SASTASSWRS GASDADTNNT SPRSSCGTPI
ELREFHDIAR VQDGSRLPAG ARLPASAKRA EELAFMRNED KSATAHVDGG SIRRDYEPRE
ICFNADGHIT GGTLRCLVER LTLSDTTIDP IFASTFLMTF RLFASPASFV QALIERYDSQ
IRSQVQPTNR ATPVSLRIYN CLKSWLETYW QQDTDAVVLD QLDVFAREAL TATLPTPAQR
LLDLIARRRY SVGGLAQRSL KRMTSIDCIK SSFQPNANDQ AQYSPPAQLL APPTPLLNKG
AMQTLRSGSF DRIGVLDFDP LELARQLTLM ESRLFCAITT RELLGQEFSK KQGTAINVKA
MSSLSTRLTG WVAETIVAEQ DAKKRAVLLK YFIKLADRCN CLRNYNCLMA IMAALDSSTI
SRLKKTWEGL SAKYKQLVEC LRKSVEHTRN YSDYRAMIRN AVPPALPFLG LYLTDLTFCQ
DGNAATRPSP QDKTLQLINF DRYQKIAKTV RDLQRFQVPY NLSEIPEIQA YLDHVLRSLP
TESNDLYRRN NTCDQGANEA RYRCQRACRN VHASRFVML
//
