ID G7E1R2_MIXOS Unreviewed; 797 AA.
AC G7E1R2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 66.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=Mo03443 {ECO:0000313|EMBL:GAA96772.1};
GN ORFNames=E5Q_03443 {ECO:0000313|EMBL:GAA96772.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA96772.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA96772.1}.
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DR EMBL; BABT02000106; GAA96772.1; -; Genomic_DNA.
DR RefSeq; XP_014565284.1; XM_014709798.1.
DR AlphaFoldDB; G7E1R2; -.
DR STRING; 764103.G7E1R2; -.
DR GeneID; 26269439; -.
DR eggNOG; KOG1131; Eukaryota.
DR HOGENOM; CLU_011312_1_0_1; -.
DR InParanoid; G7E1R2; -.
DR OMA; IREQFFR; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131}.
FT DOMAIN 7..285
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT COILED 256..298
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 797 AA; 89874 MW; 4D38A93F8DB6D408 CRC64;
MKFFIDQLPV IFPYDRIYPE QYAYVCDLKR TLDAGGNCVL EMPSGTGKTV SLLSLIVAYQ
QHYPERRKLV YCSRTVPEIE KALAELKRLM EYRRAAGCND DGFMALGLSS RKNLCIHPTI
SREKKGKVAD AKCRDLTSAW VCEKGRADPG SVELCEFHEN LGQLEPGTQL PPAVYTLEDV
KAYGEQQGIC PYFAVRRMLV HASVVIYSFH YLLDPKVAEQ VSKEMSKDAI VVFDEAHNID
NVCIESLSID LTRPMLDSAA RSVTALTDKI KEIRQTDATK LQDEYARLVE GLQGAEADQD
ENAFMGNPVL PDDILNEAVP GNIRRAEHFV AFLARFVEYL KTRMRVLHVV AEKPASFLQH
LKDITFIEKK PLRFCAERLT SLVRTLELTR IDEFSALSKV ASFATLVATY DKGFLLILEP
FETENATVPN PIFHLCCLDA SLAIKPVFDR FSSVVITSGT ISPLEMYPKM LQFTATVQES
YAMTLTRNCF LPLVITRGSD QVNISSRFEV RNDPAVVRNF GTILIEYAKA VPDGMVCFFP
SYLYMESIVA AWHDMGILNE AWKHKLIFVE TPDAAETSVA LENYRRACDN GRGAVLLSVA
RGKVSEGIDF DHHYGRCVIM FGIPYQYTES RILKARLEFL RDEHRIREND YLTFDAMRHA
AQCVGRVLRG KTDYGLMVFA DRRFAKADKR AKLPKWINHY ITDTASNLST DMALVMSKNF
LRQMAQPFEQ DTQHISLWDL SDVKARQQAR QDEAAVQAAE AEDAPMANGD VFEDEFGMIE
DTYLDDLDAA AGITAAG
//
