ID G7E7U6_MIXOS Unreviewed; 1001 AA.
AC G7E7U6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=Mo05594 {ECO:0000313|EMBL:GAA98906.1};
GN ORFNames=E5Q_05594 {ECO:0000313|EMBL:GAA98906.1};
OS Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Mixiomycetes;
OC Mixiales; Mixiaceae; Mixia.
OX NCBI_TaxID=764103 {ECO:0000313|EMBL:GAA98906.1, ECO:0000313|Proteomes:UP000009131};
RN [1] {ECO:0000313|Proteomes:UP000009131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 9802 / IAM 14324 / JCM 22182 / KY 12970
RC {ECO:0000313|Proteomes:UP000009131};
RX PubMed=21478649; DOI=10.2323/jgam.57.63;
RA Nishida H., Nagatsuka Y., Sugiyama J.;
RT "Draft genome sequencing of the enigmatic basidiomycete Mixia osmundae.";
RL J. Gen. Appl. Microbiol. 57:63-67(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 32 family.
CC {ECO:0000256|ARBA:ARBA00009003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAA98906.1}.
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DR EMBL; BABT02000165; GAA98906.1; -; Genomic_DNA.
DR RefSeq; XP_014567070.1; XM_014711584.1.
DR AlphaFoldDB; G7E7U6; -.
DR STRING; 764103.G7E7U6; -.
DR GeneID; 26262952; -.
DR eggNOG; KOG0612; Eukaryota.
DR HOGENOM; CLU_299581_0_0_1; -.
DR InParanoid; G7E7U6; -.
DR OrthoDB; 1701665at2759; -.
DR Proteomes; UP000009131; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR Gene3D; 3.90.550.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007577; GlycoTrfase_DXD_sugar-bd_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24356:SF430; MYOTONIN-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF04488; Gly_transf_sug; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009131};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 899..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..286
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 398..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 111020 MW; 8BF3D212137E7CEF CRC64;
MLDRLEVIKL LHRGDCGEVR LARATRSSQE SLLFAVKSVS RSHARKLSDQ LFPQHERQIL
LLQLSERCPA ICRLLAADSD EQNLYLITEY CPGGDLGALL DTLGPEGVQT SWIRAWLHDT
LAALTWLHAH SWVHRDLKPS NLLIAMTGQL RLTDFGSAAP LNPATGNVKR PFAEALVGTV
DYISPHMLRA HQAAINRCQT QADEQSYGAE ADLWSLGVMM YEIIVGACPF YAEDVATTYD
LILEDSEIRL PSHCSISQDG RDLLQLLLTR PGHAPPAHEL ARHPFVRFED PRSLDRFVPE
HPVIDIANLS AYQSATKPST GIDFSAFFSS PGLSILRIAK ADTPTQSDEI EHADWAFVPS
EDAWEEIGYR EPGETALPTI AHSPAWFVTP ARRSTISLSS LSRSKTTDSS TTSATKRQRR
DMSAFSARHE MVQHAVLSTA QKRRPSTHME RNESASQDQG AHMLQSEESS IEGTELDDSP
TRSRSASISL LSKSLGSSRH SRSLSDRSFT PLADFTNRSR QASQDRELPA QEPEFLNATF
RYWQCGICWR SSTATSPRLG IFHGEFCDAI GAGTPRHSVI APRAAVFPPA ADDFPWPLTR
LATSLHGIMV CSWRLAGIAT LLTALALLSI CRHRLVIVFS LASAYTFDLR TINEVGSLDD
GLACNGTYCG SADSKSQQNN YVIPNVFHSI LLGPSYVMRP SWQVSLDSCR ALHPTAEFKM
WTDESAAAFV AKEYPELLRT WLSYGQTIQR SNTLRYMLLA RLGGIYMDLD LACRVNLDPL
RRLTLVTPPA TPTGRTNAFI AAIPNHPYMN ALVSALPVYN LEWFFPYATN MFSTGCLYFS
AIDVALPAEV RRSMKILPGK AHRLSGHTFT PLFEHLGAST WHSWDSSVIM ALGHAVNSLM
SLWLPLASVA IVAIFGWHMR SRSTMQRHVR FLPSPVTEKS AARRTSRRRQ RPMLALDLSA
TRKIQFKWND KIVDLSARSG SSTPSSSGSD SSSIQAQKVL L
//
