ID G7GVB7_9ACTN Unreviewed; 452 AA.
AC G7GVB7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=F420-0:gamma-glutamyl ligase {ECO:0000313|EMBL:GAB07542.1};
GN Name=cofE {ECO:0000313|EMBL:GAB07542.1};
GN ORFNames=GOAMR_69_00610 {ECO:0000313|EMBL:GAB07542.1};
OS Gordonia amarae NBRC 15530.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1075090 {ECO:0000313|EMBL:GAB07542.1, ECO:0000313|Proteomes:UP000006023};
RN [1] {ECO:0000313|EMBL:GAB07542.1, ECO:0000313|Proteomes:UP000006023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 15530 {ECO:0000313|EMBL:GAB07542.1,
RC ECO:0000313|Proteomes:UP000006023};
RA Takarada H., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Gordonia amarae NBRC 15530.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB07542.1}.
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DR EMBL; BAED01000069; GAB07542.1; -; Genomic_DNA.
DR RefSeq; WP_005192446.1; NZ_BAED01000069.1.
DR AlphaFoldDB; G7GVB7; -.
DR STRING; 1075090.GOAMR_69_00610; -.
DR eggNOG; COG0778; Bacteria.
DR eggNOG; COG1478; Bacteria.
DR OrthoDB; 9788295at2; -.
DR Proteomes; UP000006023; Unassembled WGS sequence.
DR GO; GO:0043773; F:coenzyme F420-0 gamma-glutamyl ligase activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd20607; FbiB_C-like; 1.
DR Gene3D; 3.30.1330.100; CofE-like; 1.
DR Gene3D; 3.90.1660.10; CofE-like domain; 1.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR HAMAP; MF_01259; F420_ligase_FbiB; 1.
DR InterPro; IPR008225; F420-0_g-glutamyl_ligase.
DR InterPro; IPR002847; F420-0_gamma-glut_ligase-dom.
DR InterPro; IPR019943; F420_FbiB_C.
DR InterPro; IPR023661; FbiB.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR NCBIfam; TIGR01916; F420_cofE; 1.
DR NCBIfam; TIGR03553; F420_FbiB_CTERM; 1.
DR PANTHER; PTHR47917; -; 1.
DR PANTHER; PTHR47917:SF1; COENZYME F420:L-GLUTAMATE LIGASE; 1.
DR Pfam; PF01996; F420_ligase; 1.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF144010; CofE-like; 1.
DR SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:GAB07542.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Reference proteome {ECO:0000313|Proteomes:UP000006023}.
FT DOMAIN 21..223
FT /note="Coenzyme F420:L-glutamate ligase-like"
FT /evidence="ECO:0000259|Pfam:PF01996"
FT DOMAIN 261..432
FT /note="Nitroreductase"
FT /evidence="ECO:0000259|Pfam:PF00881"
SQ SEQUENCE 452 AA; 48143 MW; 5521A3C7C61B9C53 CRC64;
MISDHASGAP IEIYPVTGLG EFGPGSDIAG EIIGAAERSG GPGLRDGDVL VVTSKIFSKT
EGRMVPAPTG AEERDQLRRK LISDETVRIL ARKNATWITE NRNGLVQAAA GVDGSNVARD
QIALLPLDPD ASAAGLRRRI TELYGRTVAV IVTDTMGRAW RTGQTDVAIG AAGIAVSHGY
DGSVDGYGNP LIVTDIAVAD EIAAAADLAK GKLGGVPAAI VRGLRVVDDG TTARDLVRPV
EEDLFRLGTE ESIRQGHIEA LRTRRSVRTF DSREVEPELL HEAFADALTA PAPHHTHPVR
FVWLRDPARR TRLLTTMTER WRADLQSDSK TTESIDKRLG RGQILYDAPQ VVIPFLVAEG
AHTYPDARRN ACEHTMFTVA AGGAVNALLV ALSARGVGSC WIGSTIFAAD TVREVLDLDG
RWEPLGAVAI GYPTAGAGLR PPADTDGLVL EL
//
