ID   G7H5H7_9ACTN            Unreviewed;       168 AA.
AC   G7H5H7;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Putative HIT family protein {ECO:0000313|EMBL:GAB11102.1};
GN   ORFNames=GOARA_064_01040 {ECO:0000313|EMBL:GAB11102.1};
OS   Gordonia araii NBRC 100433.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1073574 {ECO:0000313|EMBL:GAB11102.1, ECO:0000313|Proteomes:UP000035088};
RN   [1] {ECO:0000313|EMBL:GAB11102.1, ECO:0000313|Proteomes:UP000035088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100433 {ECO:0000313|EMBL:GAB11102.1,
RC   ECO:0000313|Proteomes:UP000035088};
RA   Yoshida Y., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia araii NBRC 100433.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB11102.1}.
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DR   EMBL; BAEE01000064; GAB11102.1; -; Genomic_DNA.
DR   RefSeq; WP_007323177.1; NZ_JABELY010000001.1.
DR   AlphaFoldDB; G7H5H7; -.
DR   STRING; 1073574.GOARA_064_01040; -.
DR   OrthoDB; 9784774at2; -.
DR   Proteomes; UP000035088; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   CDD; cd01275; FHIT; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR039383; FHIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR   PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR   Pfam; PF01230; HIT; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          30..139
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           124..128
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        126
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT   BINDING         56
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         128
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ   SEQUENCE   168 AA;  18714 MW;  922293D1008DA64F CRC64;
     MSDHLQRLWS PHRMSYITAE PRPADATGHP FLDIPRMSDE DGLIIARGDS VYAVLNLYPY
     NPGHTMIVPY RQVADLEDLT NAEAAELMAF TQRTIRVIKD VSSPDAFNVG LNLGAAAGGS
     LSEHIHQHIV PRWTGDVNFI TVVGDTKVLP QLLRDTRSLL AEKWQELS
//