ID G7IHZ6_MEDTR Unreviewed; 1140 AA.
AC G7IHZ6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN Name=11432373 {ECO:0000313|EnsemblPlants:AES67925};
GN OrderedLocusNames=MTR_2g100870 {ECO:0000313|EMBL:AES67925.1};
GN ORFNames=MtrunA17_Chr2g0331001 {ECO:0000313|EMBL:RHN76341.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES67925.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES67925.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES67925.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES67925,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES67925.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES67925,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES67925}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES67925};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5] {ECO:0000313|EMBL:RHN76341.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN76341.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; CM001218; AES67925.1; -; Genomic_DNA.
DR EMBL; PSQE01000002; RHN76341.1; -; Genomic_DNA.
DR RefSeq; XP_003597674.1; XM_003597626.2.
DR AlphaFoldDB; G7IHZ6; -.
DR STRING; 3880.G7IHZ6; -.
DR PaxDb; 3880-AES67925; -.
DR EnsemblPlants; AES67925; AES67925; MTR_2g100870.
DR GeneID; 11432373; -.
DR Gramene; AES67925; AES67925; MTR_2g100870.
DR KEGG; mtr:11432373; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_0_0_1; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000002051; Chromosome 2.
DR Proteomes; UP000265566; Chromosome 2.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 46..313
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 688..1088
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1140 AA; 127058 MW; 00E7CDFB474802FB CRC64;
MAETTQLTRH IESYVDSSST PSHQVASLDA IVLLIKTNAL TLEALVRELD MYLTSTDTLI
RSRGILLLAE VLTRINSISL DSKTIHSLVG FFKERMADWK AVRGALVGCL ALIRRKSVVG
MVTGSDAKSI TQSFLQHLQV QSLGLYDRKL CFELLDYLLE HHVDSIASLE EDLIFGICEA
IDAEKDPECL MLAFHIVESL ARLYPDPSGL LASFARDVFD LLEPYFPIHF THQTSGDTHV
QRDDLSRTLM SAFASTPVFE PFVIPLLLQK LSSSLHSAKI DSLQYLRVCS SKYGAERIAK
YTGAIWSSLK DTLYTYLGEP DFSFTLAPTD GINFPKSEVV VEALSLLQQL IVQNSSQLVS
LIIDDEDVNF ITNSIASYEM YDTISVQEKK KLHAIGRILY ISAKTSIPSC NAVFQSLFLR
MMDKLGFSAS NIDGLQNGGI LASQSVNFGF LYLCIELLSG CRELVILSDE KRETYCTILH
SSSAVLFNAF GSVLAVTADR CPSHPDIYIG VKGLQILAMF HLDVFPIPKS TFENILKKFM
SIIIEDFGQT VLWNATLKAL FHIGSFVQKF SESEKAMSYR SFVVDKIMEM LSLDDIALPF
SLKVEALYDI GMTGMKNMLT ILQAMEGAIF TNLSEVHSNL TSHETAVQLL ECYSCKLLPW
ILKNGGAEEF VVQFAVDIWN QAGNCMDFNS PFEDKGLLDA MMKAMKVSVG CCSVESQNVT
IQKAYSTLSS HTKFQLNDVG RLPLTSGKYD ISPRDEGILL LFASVIIALR PKTHIPNIRG
LLHLFIITLL KGVVPVAQAL GSMLNKLTSK SNGAEKSDEL TLEEALDIIF NTKIWFSSNN
MLQIYNGSSN GSDIVLTDLC LGITNDRLLQ SNAICGLSWI GKGLLLRGHE KIKDITMIFT
ECLISDRRKT SVPLVEGSLE NTEKQKCDPL ARKCATEAFH VLMSDAEDCL NRKFHATVRP
LYKQRFFSSM MPIFLQLISR SDSLLSRSLL LRAFAHVMSD TPLIVILNEA KKLIPVLLDC
LFMLTEDIQD KDILYGLLLV LSGMLTEKNG QEAVIENAHI IINGLIKLVD YPHKTLVRET
AIQCLVALSE LPHVRIYPLR TQVLQAIFKC LDDTKRSVRN EAVKCRQAWA SIASSRSLRF
//
