ID G7II78_MEDTR Unreviewed; 2356 AA.
AC G7II78; A0A0C3V9X1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Pre-mRNA-processing-splicing factor 8 {ECO:0000313|EMBL:AES68165.2};
DE SubName: Full=Putative JAB1/MPN/MOV34 metalloenzyme domain, ribonuclease H-like domain, PRO8NT {ECO:0000313|EMBL:RHN76534.1};
GN Name=11425902 {ECO:0000313|EnsemblPlants:AES68165};
GN OrderedLocusNames=MTR_2g103960 {ECO:0000313|EMBL:AES68165.2};
GN ORFNames=MtrunA17_Chr2g0333191 {ECO:0000313|EMBL:RHN76534.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES68165.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES68165.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES68165.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES68165,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES68165.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES68165,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES68165}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES68165};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN76534.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN76534.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001218; AES68165.2; -; Genomic_DNA.
DR EMBL; PSQE01000002; RHN76534.1; -; Genomic_DNA.
DR RefSeq; XP_003597914.2; XM_003597866.2.
DR STRING; 3880.G7II78; -.
DR PaxDb; 3880-AES68165; -.
DR EnsemblPlants; AES68165; AES68165; MTR_2g103960.
DR GeneID; 11425902; -.
DR Gramene; AES68165; AES68165; MTR_2g103960.
DR KEGG; mtr:11425902; -.
DR eggNOG; KOG1795; Eukaryota.
DR HOGENOM; CLU_000380_3_0_1; -.
DR OrthoDB; 246127at2759; -.
DR Proteomes; UP000002051; Chromosome 2.
DR Proteomes; UP000265566; Chromosome 2.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR GO; GO:0030623; F:U5 snRNA binding; IBA:GO_Central.
DR GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2123..2254
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..39
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2356 AA; 275628 MW; 545CA3B3E39A9394 CRC64;
MWNNGQIAPP GTTVPSIPPP QASQPSYTVL PPPPPPAVET EADAEARLEE KARKWQQLNS
KRYSDKRKFG FVETQKEDMP PEHVRKIIRD HGDMSSKKFR HDKRVYLGAL KFIPHAVYKL
LENMPMPWEQ VRDVRVLYHI SGAITFVNEI PWVVEPIYLA QWGTMWIMMR REKRDRRHFK
RMRFPPFDDE EPPLDYADNL LDVDPLEPIQ LELDEEEDSA VYTWFYDHKP LVKTKLINGP
SYRKWHLSLP IMATLHRLAG QLLSDLSDRN YFYLFDMESF FTAKALNMCI PGGPKFEPLY
RDMEKGDEDW NEFNDINKLI IRSPLRTEYR IAFPHLYNNR PRKVRLCIYH TPMVMYIKTE
DPDLPAFYYD PLIHPITSAN KERREKKIYD EEDDDDWVLP DGVEPFLKDT QLYTDTTAAG
ISLLFAPRPF NMRSGRMRRA EDIPLVSEWY KEHCPPSYPV KVRVSYQKLL KCFVLNELHH
RPPKAQKKKH LFRSLQATKF FQTTELDWVE AGLQVCRQGY NMLNLLIHRK NLNYLHLDYN
FNLKPVKTLT TKERKKSRFG NAFHLCREIL RLTKLVVDAN VQFRLGNVDA FQLADGLQYT
FSHVGQLTGM YRYKYRLMRQ IRMCKDLKHL IYYRFNTGPV GKGPGCGFWA PMWRVWLFFL
RGIVPLLERW LGNLLARQFE GRHSKGVAKT VTKQRVESHF DLELRAAVMH DVLDAMPEGI
KQNKARTILQ HLSEAWRCWK ANIPWKVPGL PVPIENMILR YVKSKADWWT NVAHYNRERI
RRGATVDKTV CRKNLGRLTR LWLKAEQERQ HNYLKDGPYV TPEEAVAIYT TTVHWLESRK
FSPIPFPPLS YKHDTKLLIL ALERLKESYS VAVRLNQLQR EELGLIEQAY DNPHEALSRI
KRHLLTQRAF KEVGIEFMDL YSYLIPVYEI EPLEKITDAY LDQYLWYEGD KRHLFPNWIK
PADSEPPPLL VYKWCQGINN LQSVWDTSDG QCVVMLQTKF EKFFEKIDLT MLNRLLRLVL
DHNIADYVTA KNNVVLSYKD MSHTNSYGLI RGLQFASFVV QYYGLVLDLL LLGLTRASEI
AGPPQMPNEF ITYWDTKVET RHPIRLYSRY IDRVHILFRF THEEARDLIQ RYLTEHPDPN
NENMVGYNNK KCWPRDARMR LMKHDVNLGR SVFWDMKNRL PRSITTLEWE NSFVSVYSKD
NPNLLFSMCG FEVRILPKIR MTQEAFSNTR DGVWNLQNEQ TKERTAVAFL RVDDEHMKVF
ENRVRQILMS SGSTTFTKIV NKWNTALIGL MTYFREATVH TQELLDLLVK CENKIQTRIK
IGLNSKMPSR FPPVIFYTPK EIGGLGMLSM GHILIPQSDL RYSQQTDVGV THFRSGMSHE
EDQLIPNLYR YIQPWESEFV DSQRVWAEYA LKRQEAQAQN RRLTLEDLED SWDRGIPRIN
TLFQKDRHTL AYDKGWRVRT DFKQYQVLKQ NPFWWTHQRH DGKLWNLNNY RTDVIQALGG
VEGILEHTLF KGTYFPTWEG LFWEKASGFE ESMKYKKLTN AQRSGLNQIP NRRFTLWWSP
TINRANVYVG FQVQLDLTGI FMHGKIPTLK ISLIQIFRAH LWQKIHESVV MDLCQVLDQE
LDALEIETVQ KETIHPRKSY KMNSSCADIL LFAAHRWPMS KPSLVAESKD VFDQKASNKY
WIDVQLRWGD YDSHDIERYT RAKFMDYTTD NMSIYPSPTG VMIGLDLAYN LHSAFGNWFP
GSKPLLQQAM NKIMKSNPAL YVLRERIRKG LQLYSSEPTE PYLSSQNYGE IFSNQIIWFV
DDTNVYRVTI HKTFEGNLTT KPINGAIFIF NPRTGQLFLK VIHTSVWAGQ KRLGQLAKWK
TAEEVAALVR SLPVEEQPKQ IIVTRKGMLD PLEVHLLDFP NIVIKGSELQ LPFQACLKIE
KFGDLILKAT EPQMVLFNIY DDWLKSISSY TAFSRLILIL RALHVNNEKA KMLLKPDKTI
VTEPHHIWPS LSDDQWMKVE VALRDLILSD YAKKNNVNTS ALTQSEIRDI ILGAEITPPS
QQRQQIAEIE KQSHEANQVT AVTTRTTNVH GEELIVTTTS PYEQGAFASK TDWRVRAISA
TNLYLRVNHI YVNSEDIKET GYTYIMPKNI LKKFICIADL RTQISGYLYG ISPPDNPQVK
EIRCIVMPPQ WGTHQQVHLP SALPEHDFLN DLEPLGWMHT QPNELPQLAP QDLTSHAKVL
ENNKQWDGEK CIILTCSFTP GSCSLTAYKL TPSGYEWGRI NKDTGSNPHG YLPTHYEKVQ
MLLSDRFLGF YMIPDNGPWN YNFMGVRHAS GMKYGVKLGT PREYYHEDHR PTHFLEFSNM
EEGETITEGD REDTFS
//
