ID G7IQB0_MEDTR Unreviewed; 1791 AA.
AC G7IQB0; A0A0C3V2D3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Animal HSPA9 nucleotide-binding domain protein {ECO:0000313|EMBL:AES65523.2};
GN Name=11440666 {ECO:0000313|EnsemblPlants:AES65523};
GN OrderedLocusNames=MTR_2g040370 {ECO:0000313|EMBL:AES65523.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES65523.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES65523.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES65523.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES65523,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES65523.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES65523,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES65523}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES65523};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001218; AES65523.2; -; Genomic_DNA.
DR RefSeq; XP_003595272.2; XM_003595224.2.
DR PaxDb; 3880-AES65523; -.
DR EnsemblPlants; AES65523; AES65523; MTR_2g040370.
DR Gramene; AES65523; AES65523; MTR_2g040370.
DR eggNOG; KOG0101; Eukaryota.
DR Proteomes; UP000002051; Chromosome 2.
DR ExpressionAtlas; G7IQB0; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR Gene3D; 3.30.30.30; -; 2.
DR Gene3D; 3.30.420.40; -; 4.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR19375:SF532; HEAT SHOCK 70 KDA PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 2.
DR PROSITE; PS00329; HSP70_2; 2.
DR PROSITE; PS01036; HSP70_3; 2.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 13..179
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1791 AA; 201577 MW; D53C24B3398FC9B5 CRC64;
MTQPSLSVSS SFTTYDVFIS FRGIDTRNNF TRDLYDILDQ NGIHTFFDEQ EIQKGEEITP
SLLQAIQQSR IFIVVFSNNY ASSTFCLNEL VMILECSNTH GRLFLPVFYD VDPSQVRHQS
GAYGDALKKH EKRFSDDKVQ KWRDALCQAA NVSGWDFQHG SQSEYKFIGN IVEEVTKKIN
RTTLHVADNP VALEYPMLEV ASLLGSGPEK GTNMVGIYGI GGVGKSTLAR AVYNHISDQF
DGVCFLAGIR ESAINHGLAQ LQETLLSEIL GEEDIRIRDV YRGISIIKRR LQRKKVLLVL
DDVDKVNQIQ VLAGGHDWFG PGSKIVVTTR DKHLLAIHEI LNLYEVKQLN HEKSLDLFNW
HAFRNRKMDP CYSDISNRAV SYASGLPLAL EVIGSHLFGK SLDVWKSSLD KYERVLHKEI
HEILKVSYDD LDDDQKGIFL DIACFFNSYE MSYAKEMLYL HGFSAENGIQ VLTDKSLIKV
DGNGCVRMHD LVQDMGREIV RQESTVEPGR RSRLWFDDDI VHVLETNTGT DTIEVIIMNL
CNDKEVQWSG KAFNKMKNLK ILIIRSARFS RGPQKLPNSL RVLDWNGYPS QSLPADFNPK
NLMILSLPES CLVSFKLLKV FESLSFLDFK GCKLLTELPS LSGLVNLGAL CLDDCTNLIR
IHESIGFLNK LVLLSSQRCK QLELLVPNIN LPSLETLDIR GCSRLKSFPE VLGVMENIRY
VYLDQTSIGK LPFSIRNLVG LRQMFLRECM SLTQLPDSIR ILPKLEIITA YGCRGFRLFE
DKEKVGSEVF PEAMLVCKEG SVESLDMSSL NICPDNVIEV FSTSILDGNV VFMREGIAKG
RGNWYRHESN ESPLRFWFQN KFPRIALCCT VEPPVCKDNM LLDFKLSVLI NGTEQFTSSC
NYIFSAEQII LLCDLVCKVE RSYLEHEWNQ VDILYEFKYL MPCGSKSIMA THEMTTTRNP
SWSFIYAYEE DNKVVVKFLS QFVEWVEQHR RYFSYYWFGS VLYTRSLSPL VKKKRPVVPF
PVKKLEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS EHLIGDAALN
QVSSNPINTV FDAKRLIGRR FSDPSVQSDM KLWPFKIISG PDEKPMIGVN YSGKVKQFAA
EEISSMVLTK MREVAEAYLG SAIKNAVVTV PAYFNFSQRQ ATKHAGAIAG LNFMRIINEP
TAAAIAYGFD TTSVGEKNVL IFDLGGGTFD VSLLTIEECN FQVKATAGDA HLGGEDFNNR
MVNHFVREFK RKNKKDISGN PRALMRLRTA CERAKRALSS TAQTTIEIDC LFEGIDFYTP
ITRARFEELN LDLFRECMEQ VEKCLSHAGM YKGSVHDVVL VGGSTRIPKV QQLLQDFFNR
KELCKSINPD EAVAYGAAVY TAILNVEKLE VPAIGIDLGT TYSCVGVWQH DHVEIITNDQ
GNRTTPSYVA FTDSEHLIGD AAMNQVASNP INTVFDAKRL IGRRFSDPSV QCDMKLWPFK
IISGLGEKPM IGVNYNGEDK QFAAEEISSM VLWKMREIAE AYFGSTIRNA VVTVPAYFND
SQIQVTKDAA LFAGLNVMEI IDEPTAAAIA YGFDTTSVGE KNVLIFDLGG GTFDVSLLTT
IEECNFQVKA TAGDAHLGGE DFNNRMVNHF VQEFKRKNKK DISGNPRALM KLRTACERAK
RALSSTSQTT IEIDCLFEGI DFYTPITRAR FEELNLDLFR ECMEQVEKCL RRAGMNKGSV
HDVVLVGGST KIPKVQQLWQ DVFNGKDLCK SINPDEAVAY GAAVYAAILS G
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