ID G7IVR5_MEDTR Unreviewed; 590 AA.
AC G7IVR5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DNA (Cytosine-5)-methyltransferase DRM1/2 {ECO:0000313|EMBL:AES68648.2};
GN Name=11419444 {ECO:0000313|EnsemblPlants:AES68648};
GN OrderedLocusNames=MTR_3g011150 {ECO:0000313|EMBL:AES68648.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES68648.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES68648.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES68648.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES68648,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES68648.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:AES68648.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES68648,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES68648}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES68648};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; CM001219; AES68648.2; -; Genomic_DNA.
DR RefSeq; XP_003598397.2; XM_003598349.2.
DR AlphaFoldDB; G7IVR5; -.
DR STRING; 3880.G7IVR5; -.
DR PaxDb; 3880-AES68648; -.
DR EnsemblPlants; AES68648; AES68648; MTR_3g011150.
DR GeneID; 11419444; -.
DR Gramene; AES68648; AES68648; MTR_3g011150.
DR KEGG; mtr:11419444; -.
DR eggNOG; ENOG502QR6U; Eukaryota.
DR HOGENOM; CLU_006805_2_0_1; -.
DR OrthoDB; 913973at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0006306; P:DNA methylation; IBA:GO_Central.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR030380; SAM_MeTfrase_DRM.
DR InterPro; IPR015940; UBA.
DR PANTHER; PTHR23068:SF25; DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2; 1.
DR PANTHER; PTHR23068; DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS51679; SAM_MT_C5; 1.
DR PROSITE; PS51680; SAM_MT_DRM; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 138..180
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 258..589
FT /note="SAM-dependent MTase DRM-type"
FT /evidence="ECO:0000259|PROSITE:PS51680"
FT REGION 96..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 590 AA; 66370 MW; D291C12D8639E782 CRC64;
MGDDSSLESD NFDWKTDDEL EIESFNSLSS TIPSRQTITA ASVEARSSAG PSNTKVLDHF
ISMGFPGEVV SKVIQEYGEE DEDKLLEEIL TYSALESSSQ QHQQVEPDPT SSEYAGSSWD
DLSDGNSFSD EETPKSVSRN DDTLLSLVNM GFKEEEALMA IERLGLDSSL DDLVDFIGVA
QLVKEEDSLL PPEDKQQCSG HPKPRKRSLY EYEVLGKKKR KVSDKRTPCE EEDDGQTLNL
PNPMMGFGVP NEPKSIITHR TLPENAIGPP YFYYENVAIT PKGVWQKISR FLYDVQPEYV
DSKYFCAAAR KRGYVHNLPI ANRFPLLPLP PRTILDAFPP LRRWWPSWDP RKNLNCLQTV
HGSAQTTDRI RKKLESCEEF EEPSESVKKY VLEQCRKWNL VWVGKNKVAP LEPDEVEMLL
GFPKNHTRGG GISRTDRFKS LGNSFQVDTV AYHLSVLKEM YPNGINLLSL FSGIGGAEVA
LHRLGVPLNN VVSVEKSEVN RNIVRSWWDQ TNQKGNLIDL DDVQHLDAER LEQLMSACGG
FDLVIGGSPC NNLAGSNRVS RIGLEGTESA LFYDYFRILD LVKAMAPRFQ
//