ID G7IZ28_MEDTR Unreviewed; 1143 AA.
AC G7IZ28;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=LRR and NB-ARC domain disease resistance protein, putative {ECO:0000313|EMBL:AES69056.1};
DE SubName: Full=Putative P-loop containing nucleoside triphosphate hydrolase, leucine-rich repeat domain, L {ECO:0000313|EMBL:RHN65916.1};
GN Name=11422899 {ECO:0000313|EnsemblPlants:AES69056};
GN OrderedLocusNames=MTR_3g021170 {ECO:0000313|EMBL:AES69056.1};
GN ORFNames=MtrunA17_Chr3g0085111 {ECO:0000313|EMBL:RHN65916.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES69056.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES69056.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES69056.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES69056,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES69056.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES69056,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES69056}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES69056};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5] {ECO:0000313|EMBL:RHN65916.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN65916.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001219; AES69056.1; -; Genomic_DNA.
DR EMBL; PSQE01000003; RHN65916.1; -; Genomic_DNA.
DR RefSeq; XP_003598805.1; XM_003598757.1.
DR AlphaFoldDB; G7IZ28; -.
DR PaxDb; 3880-AES69056; -.
DR EnsemblPlants; AES69056; AES69056; MTR_3g021170.
DR GeneID; 11422899; -.
DR Gramene; AES69056; AES69056; MTR_3g021170.
DR KEGG; mtr:11422899; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR OrthoDB; 1216134at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR Proteomes; UP000265566; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:RHN65916.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 11..96
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 158..399
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1143 AA; 132106 MW; 4EF271ECEE1DAD64 CRC64;
MAEVVVRRAF LSPVIQLICE RLASTDLSDY FHEKHVKKLE ITLVSINKVL DDAETKQYEN
LDVKNWVDDI RNKIYEVEQL LDVIATDAAQ QKGKIQRFLS GSINRFESRI KVLIKRLKVL
AKQNDRLQLH QDYCYHEDGA SNFGTSSFMN ESIIYGREHE KEEIIDFLLS YSHGDNRVPI
ISIVGLNGIG KTTLAQLVYN DHMTRDQFEV IGWIHVSKSF NYRHLMKSIL KSISLSTLYD
EDKEILKHQL QQRLAGKKYL LVLDDVWIKH WNMLEQLLLI FNPDSFRGRM IVTTHDKEVA
SVMRSTQILH LRQLEESDSW SLFVRHAFEG RNMFEYPNLE SIGMKIVEKC GGSPFALKTL
GILLQRRFSE NEWVKILETD LWSLPKSDRS IYSFLRQSYL NLPSNLKHCF AYCSIFPKGY
KFEKDGLIKL WMAQGLLKCC GKDKNEEELG NEFFDHLVSM SFFQQSAIMP LWAGKYYFIM
HDLASDLAKS LTGESHLRIE GDNVQDIPQR TRHIWCCLDL EDGDRKLKQI RDIKGLQSLM
VEAQGYGDQR FQISTDVQLN LFFRLKYLRR LSFNGCNLLE LADEIRNLKL LRYLDLSYTD
ITSLPNSICM LYNLHTLLLE ECFKLTELPS NFGKLINLRH LNLKGTHIKK MPKEIRVLIN
LEMLTDFVVG EQHGYDIKLL EELNHLKGRL QISGLKNVTD PADAMAANLK DKKHLQELIM
SYDEWREMEG SETEARLLVL EALQPNRNLM RLTINDYRGS SFPNWLGDHH LPNLVSLELF
GCKHCSQLPP LGQFHSLKKL SISGCHGIEN IGSEFFGYNY AAFRSLETLR VEYMSEWKEW
LCLEGFPLLQ ELCLKQCPKL KSALPHHLPC LQKLEIIDCE ELEASIPKAA NISDIELKRC
DGISINELPS CLIRAILCGT HVIESTLEKV LINSAFLKEL EVEDFFGRNM EWFSLYMCSC
YSLRTLTITG WHSSSLPFAL HVFNNLNSLV LYDCPLLESF FGRQLPCNLG SLRIERCPNL
MASIEEWGLF KLKSLKQLSL SDDFEIFAFL PKETMLPSSI TSLELTNCSN LRKINYNGLF
HLTSLESLYI DDCPCLESLP DEGLPRSLST LSIRDCPLLK KLYQKEQGER RHTISHIPDV
TIS
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