ID G7IZ41_MEDTR Unreviewed; 1132 AA.
AC G7IZ41;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=NBS-LRR type disease resistance protein {ECO:0000313|EMBL:AES69069.1};
GN Name=11411709 {ECO:0000313|EnsemblPlants:AES69069};
GN OrderedLocusNames=MTR_3g021380 {ECO:0000313|EMBL:AES69069.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES69069.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES69069.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES69069.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES69069,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES69069.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES69069,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES69069}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES69069};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; AES69069.1; -; Genomic_DNA.
DR RefSeq; XP_003598818.1; XM_003598770.2.
DR AlphaFoldDB; G7IZ41; -.
DR PaxDb; 3880-AES69069; -.
DR EnsemblPlants; AES69069; AES69069; MTR_3g021380.
DR GeneID; 11411709; -.
DR Gramene; AES69069; AES69069; MTR_3g021380.
DR KEGG; mtr:11411709; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR OrthoDB; 1216134at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 35..99
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 161..388
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT COILED 106..133
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1132 AA; 130274 MW; 0E0689C72B8028AD CRC64;
MNIMEDVFHG GAFLSPVIRL ICKSLASTDF RDYFDKGLVN KLETTLNFIN LVLDDAETKQ
YEDLGVKCWL DDVSNEVYEL EQLLDVIATD AAQQKGKIQR FLSGSINRFE SRIKVLLKRL
EFLAMEKSRL ELQEFTNYLY EERASGFATS FMAESIIYGR EREKEEIIKF LLSDSYNRNQ
VSIISIVGLT GMGKTALAQL VYNDHRIQEQ FEFKAWVHVS DESFDCLRLN KEILNHQLQK
WLAGNKYLLV LDDAWIKNRN MLERLLLLFN QGYIRGKMIV TTNDKEVASV MRSTRIIHLR
QLEESDSWNL FVRHAFEGRN MFEYPNLESI GKKIVEKCGG LPSALKTLGI LLQRKFSENE
WVKILETDLW RLPKGDNSNI YSALRMSYLS LPSNLKHCFA YCSIFPKGYE FEKGELIKLW
MAKGLLKGIT KKEEELGNKF FNDLVSMSFF QPSAIMPFWA GKYYFIMHDL INDLATSMSG
EFCLRIEGVK VQDIPQRTRH IWCRLDLEDG DRKLKQIHNI KGLQSLMVEE QGYGEKRFKI
STNVQQSLFS RLKYLRILSF SGCNLLELAD EIRNLKLLRY LDLSYTEITS LPDSICMLYN
LHTLLLEECF KLTELPSNFH NLINLCHLNL KGTHIKKMPK KIRELINLEM LTDFVVEEQH
GYDIKQLAEL NHLKGRLRIS GLKNVADPAV AMAANLKEKK HLEELSLSYD EWREMDGSET
EARVSVLEAL QPNRNLMRLT INDYRGSSFP NWLGDLNLPN LVSLELVGCK HCSQLPPLGK
FPSLKKLSIS GCHGIKIIGS EFCGYNSSNV AFRSLETLRV EYMSEWKEWL CLEGFPLLQE
LCLKQCPKLK SALPHHLPCL QKLEIIDCEE LEALIPKAAN ISDIELKRCD GILINELPSS
LKTAILCGTH VIESTLEKVL INSAFLEELE VEDFFGRNME WSSLHVCSCY SLCTLTITGW
HSSSLPFALH LFTNLNSLVL YDCPWLESFF GRQLPCNLGS LRIERCPNLM ASIEEWGLFQ
LKSLKQFTLS DDFEIFESFP EESMLPSTIN SLELTNCSNL TKINYKGLLH LTSLESLYIE
DCPCLDSLPE EGLPSSLSTL SIHDCPLIKQ LYQKEQGEHW HTISHIPYVI IS
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