ID G7J0V7_MEDTR Unreviewed; 1248 AA.
AC G7J0V7; A0A0C3VE83;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=NB-ARC domain disease resistance protein, putative {ECO:0000313|EMBL:AES69677.2};
GN OrderedLocusNames=MTR_3g033110 {ECO:0000313|EMBL:AES69677.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES69677.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES69677.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES69677.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES69677,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES69677.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES69677,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES69677}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES69677};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; AES69677.2; -; Genomic_DNA.
DR RefSeq; XP_003599426.2; XM_003599378.2.
DR AlphaFoldDB; G7J0V7; -.
DR PaxDb; 3880-AES69677; -.
DR EnsemblPlants; AES69677; AES69677; MTR_3g033110.
DR Gramene; AES69677; AES69677; MTR_3g033110.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1228; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 10..100
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 168..415
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1248 AA; 141170 MW; EB9D390B5A755150 CRC64;
MAAALVGGAF LSATIQTIAE KLTSSEFRGF IKNTKFNYSQ LAELKTTLFA LQAVLVDAEQ
KQFNDLPVKQ WLDDLKDAIF DSEDLLDLIS YHVLRSTVEK TPVDQLQKLP SIIKINSKME
KMCKRLQTFV QQKDTLGLQR TVSGGVSSRT LSSSVLNESD VVGRNDDKDR LINMLVSDVG
TSRNNNLGVA AIVGMGGVGK TTLAQFVYND AKVEQHFDFK AWVCVSEDFD VIRATKSILE
SIVRNTTSAG SKVWESDNLD ILRVELKKNS REKRFLFVLD DLWNDDYNDW LELVSPLNDG
KPGSSVIITT RQQKVAEVAH TFPIQELEPL SHEDCWSLLS KHAFGSKDSD HSKYPNLEEI
GRKIAKKCGG LPIAAKTLGG LMRSKVVEKE WSSILNSNIW NLRNDKILPA LHLSYQYLPS
HLKRCFAYCS IFPKDYPLER KKLVLLWMAE GFLDYSQDEN AMEEIGDDCF AELLSRSLIQ
QLSNDAHEKK CVMHDLVHDL ATFVSGKSCC RLECGDIPEK VRHFSYNQEY YDIFMKFEKL
YNFKCLRTFL STYSREGIYN YLSLKVVDDL LPSQNRLRVL SLSRYRNITK LPDSIGNLVQ
LRYLDTSFTY IESLPDTTCN LYNLQTLNLS NCTALTELPI HVGNLVSLRH LDITGTNIMG
KRHVGLSIKE LRKFPNLQGK LTIKNLDNVV DAREAHDANL KSIETIEELE LIWGKQSDDS
QKVKVVLDML QPPINLKSLN ICLYGGTSFP SWLGSSSFYN MVSLSISNCE NCVTLPSLGQ
LPSLKDLEIC GMEMLETIGP EFYYAQIEEG SNSSFQPFPS LERIMFDNML NWNEWIPFEG
IKFAFPQLKA IKLRNCPELR GHLPTNLPSI EEIVIKGCVH LLETPSTLHW LSSIKKMNIN
GLGESSQLSL LESDSPCMMQ DVEIKKCVKL LAVPKLILKS TCLTHLGLDS LSSLTAFPSS
GLPTSLQSLN IQCCENLSFL PPETWINYTS LVSLKFYRSC DTLTSFPLDG FPALQTLTIC
ECRSLDSIYI SERSSPRSSS LESLEIISPD SIELFEVKLK MDMLTALERL TLDCVELSFC
EGVCLPPKLQ SIKISTQKTA PPVTEWGLQY LTALSDLGIV KGDDIFNTLM KESLLPISLV
TLTIRDLSEM KSFDGKGLRH LSSLQRLRFW DCEQLETLPE NCLPSSLKLL DLWKCEKLKS
LPEDSLPDSL KRLLIWECPL LEERYKRKEH WSKIAHIPVI SINYQVTI
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