ID G7J7A7_MEDTR Unreviewed; 1664 AA.
AC G7J7A7; A0A0C3VJX0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:AES71667.2};
GN Name=11438935 {ECO:0000313|EnsemblPlants:AES71667};
GN OrderedLocusNames=MTR_3g080470 {ECO:0000313|EMBL:AES71667.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES71667.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES71667.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES71667.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES71667,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES71667.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES71667,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES71667}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES71667};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; AES71667.2; -; Genomic_DNA.
DR RefSeq; XP_003601416.2; XM_003601368.2.
DR PaxDb; 3880-AES71667; -.
DR EnsemblPlants; AES71667; AES71667; MTR_3g080470.
DR Gramene; AES71667; AES71667; MTR_3g080470.
DR eggNOG; ENOG502R41B; Eukaryota.
DR Proteomes; UP000002051; Chromosome 3.
DR ExpressionAtlas; G7J7A7; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 10..176
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 1271..1437
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1664 AA; 189564 MW; 1409A800E46E7958 CRC64;
MEDCSQNSKW KYHVFLSFRG EDTRLGFTDH LYAALVRKSI ITFRDDEELA RGEVISQKLL
LAIEESLSAV LIISKNYANS AWCLDELVKI LESKRLLGQQ VFPVFYGVDP SDVRNQRGSF
AEAFKKHEEK FSESKEKVQK WRDALREVAN LSGWDSKDQH ETKLIEEVIA QVWKRLELKF
PSYNDGLVAI DVRLEELYST LKLGLEDVHF IGIWGMGGIG KTTLTTALFK KIKSQFDVSC
FIANVREVSG ERNQYLQQLQ NKILSHLNIK GMVIETLSQG KDSLRNLLSN KKVLLVLDDV
SSKSQLENLA GSQEWFGRGS RIIVTTRDKH LLISHDVLFE MYESKILNKS ESLHLFCEKA
FKEDAPKEGF VELSESVVEY ARGLPLALEV LGSFLCGRSL SDWEDALIKI KQVPHDDILN
KLRISYDMLE DEHKTIFLDI ACFFKGWYKH KVIQILESCG LHPTVGINVL IEKSLLTFDG
RVIWLHDMLE EMAKTIVIQE SPNDPGRRSR LWSLEDIDQV LKKNKGTEIV QGIVLKSSPS
TLYEAHWDPE AFTKMGNLRL LIILCDLHLS LGLKCLSSSL KVLVWWGYPL NSLPVGIQLD
ELVHLQMINS KIKQLWNGNE YYGKLKVIDL SNSKDLRQTP NVSGIPNLEE LYFNDCIKLV
EVHQSIRQHK KLRILSLMGC VDLKIFPKKL EMFSLKMLFL SYCSNIKRLP DFGKNMTCIT
ELNLLNCENL LSLPNSICNL KSLRILNISG CSKICNLPDG INQIMALEDI DLSRTAIRDL
DPSLLQLGNL KRLSLRSCRD PATNSSWNFH LPFGKKFSFF PAQTTSLTLP PFLSGLSSLT
ELDLSDCNLT DSSIPHDIDC LSSLERLILS GNNFVCLPTH YISNLSKLRY LELEDCPQLQ
SLPMLQPQVR LYVTDSDARE AYALDPQKIW KLFESSDKKL LHSSLYRVPD FPYPMYFEMP
SRFDNQNFFP LTSSYVSKLD AIASVKVDIP DDCLLSDWWG VAVFVALEAE GFVARHMRLS
WNFDTLGPED GPSLSLLTGS TAANDSYLFT LVVSGDFIYI QRHLSGDPKF MRKQFSKHRK
PELSENSSLR FEVQVEGCKI RKCGWRMLRK EDYLEDLKML NSSGLVVAHS DSGHSAGMNQ
SSEVESKVKE TTALDVQNIE RSNENFSLGK MLHNIRQGLG VSMLALISMM VGATIFHSPV
NGLRFKKSAP TNETVTNKLF KSQWISSNDI VLKVNTPQLP DNPRNRKVLQ SYKLAHCYSV
SMEDFSQNSK WKYHVFLSFR GEDTRLGFTD HLYASLVRKS IITFRDDEEL ARGEVISQKL
LHAIEESLSA IVIISKNYAD SAWCLDELVK ILESKRLLGQ QVFPIFYGVD PSDVRNQRGS
FAEAFKKHEE KFSESKEKVQ RWRDALREVA NFSGWDSKDQ HETKLIEEVI AQVWKRLELK
FPSYNDGLVA IDVRLEELYS TLKLGLEDVH FIGIWGMGGI GKTTLTTALF KKIKSQFDVS
CFITNVREGT ELVQGIVLKS SPSTLYEAHW DPEAFSKMGN LRLLIILCDL HLSLGLKCLS
SSLKVPVWWG YPLNSLPVGV QLDELVNLQM INSKVKQLWN GNKYYGKLKV IDLSNSKDLR
QTPNVSGIPN LEELYLNDCT KLVEVHQSIR QHKKLRVCLD GGMF
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