ID G7J7Y4_MEDTR Unreviewed; 582 AA.
AC G7J7Y4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Long-chain acyl-CoA synthetase {ECO:0000313|EMBL:AES70878.1};
DE SubName: Full=Putative 4-coumarate--CoA ligase {ECO:0000313|EMBL:RHN68067.1};
DE EC=6.2.1.12 {ECO:0000313|EMBL:RHN68067.1};
GN Name=11419002 {ECO:0000313|EnsemblPlants:AES70878};
GN OrderedLocusNames=MTR_3g064420 {ECO:0000313|EMBL:AES70878.1};
GN ORFNames=MtrunA17_Chr3g0109731 {ECO:0000313|EMBL:RHN68067.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES70878.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES70878.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES70878.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES70878,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES70878.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES70878,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES70878}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES70878};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN68067.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN68067.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CM001219; AES70878.1; -; Genomic_DNA.
DR EMBL; PSQE01000003; RHN68067.1; -; Genomic_DNA.
DR RefSeq; XP_003600627.1; XM_003600579.2.
DR AlphaFoldDB; G7J7Y4; -.
DR STRING; 3880.G7J7Y4; -.
DR PaxDb; 3880-AES70878; -.
DR EnsemblPlants; AES70878; AES70878; MTR_3g064420.
DR GeneID; 11419002; -.
DR Gramene; AES70878; AES70878; MTR_3g064420.
DR KEGG; mtr:11419002; -.
DR eggNOG; KOG1176; Eukaryota.
DR HOGENOM; CLU_000022_59_5_1; -.
DR OMA; FYYTANG; -.
DR OrthoDB; 2596785at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR Proteomes; UP000265566; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd12118; ttLC_FACS_AEE21_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43859; ACYL-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR43859:SF2; BUTYRATE--COA LIGASE AAE11, PEROXISOMAL; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:RHN68067.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 23..408
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 458..540
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 582 AA; 65127 MW; ED76327B9AD0194C CRC64;
MDNLPKCRAN YTILTPLTFL MRASASYANR TSVIHEGTRF TWSQTYDRCR RLASSLRALN
IAKNDVVSVL APNIPAMYEM HFAVPMAGAV LNTINHRLNA ANIATILQHS EAKVFFVDYE
FVSKAKDALR LLMEEKDQTE QYSSLPLVIV IDDINNPTGI RLGELEYEQM VHHGNPNYLP
EEIQDEWSPI TLNYTSGTTS EPKGVVYSHR GAYLSTLSLI LGWEMGSEPV YLWTLPMFHC
NGWTFTWGVA ARGGTNICIR NTAASDIYRA INLYNVTHMC CAPIIFNIIL GAKPSEKRVI
KSPVNILTGG APPPASLLEK IEPLGFHVTH AYGLTEATGP ALVCEWQKKW NVLPKREQSM
LKARQGVSVL TLADVDVKNL ETMESVVRDG KTMGEIMLKG SGIMMGYFKD KEATAKAFGD
GWFRTGDVGV IHKDGYLEIK DRSKDVIISG GENISSVEVE NVLYSHPKVL EAAVVAMPHP
KWGESPCAFV TLNKNEEVKS DFCCVTEDEI ITYCRKNLPH FMVPKMVVFM EDLPKTLTGK
IQKFELRAKA KCFVVNDEKK NNKKPNNQVN HNNDQIMALS RL
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