ID G7J9J4_MEDTR Unreviewed; 1254 AA.
AC G7J9J4; A0A0C3VKD6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:AES71833.2};
GN Name=11435666 {ECO:0000313|EnsemblPlants:AES71833};
GN OrderedLocusNames=MTR_3g083250 {ECO:0000313|EMBL:AES71833.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES71833.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES71833.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES71833.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES71833,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES71833.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES71833,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES71833}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES71833};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; AES71833.2; -; Genomic_DNA.
DR RefSeq; XP_003601582.2; XM_003601534.2.
DR AlphaFoldDB; G7J9J4; -.
DR STRING; 3880.G7J9J4; -.
DR PaxDb; 3880-AES71833; -.
DR EnsemblPlants; AES71833; AES71833; MTR_3g083250.
DR GeneID; 11435666; -.
DR Gramene; AES71833; AES71833; MTR_3g083250.
DR KEGG; mtr:11435666; -.
DR eggNOG; KOG4751; Eukaryota.
DR HOGENOM; CLU_004336_0_0_1; -.
DR OrthoDB; 5484321at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF00634; BRCA2; 3.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 890..931
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 408..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 138038 MW; A63591396B8DEF5E CRC64;
MSSWQILPDA DNNYRWQINS DDTSNVIPPS PPPFSIPTPP LPSMYDLLIH ASASHLFQPQ
EEENAIDDSF GFANSLFKTG SGRKVTISSK GLVRAKTLLG LGLHEETVGA NIQTPQNAKK
FNSFHQDEPR LQVIDSCKKT SAASFQSPLV SRLKNGFENK IVQPDTGSRS GVGAKQAPIK
FQTGVSNIQA PQTQNASFFD AFDEELPDLQ LMDSCKKMSA ASFQSPLVGR LHMGSENKVA
QLDSGSVSGG KDAPLTNSLF KTGSGRKVTI SSKGLVRAKT LLGLGLHEET VGANIQTPQN
AEKLHAFDEE LPHVQLMDSC KMMSSASFQS PLVGRLKNGF ESKFVQPDSG GGAKQAPIKF
QTASGRSLSI SGDALKRARR LLGDPDLGDF FDGGDSLFSF LDQGQTSTIT SSAERSESKN
THTPLVHQMT PENHPNHMSK SFTYPLQPSK QMEFSNKLRN EGNGNNLIVK FDDVVNESDC
GCKSSITPGQ KPLYNKNEVA DTTIKSSSLN GFSSRMDSRE KPLGRALVDI SNTIKTVHTN
HKQPASGKRR IGLHATVSSF KKPRISNISA SGGQDVQYFS NDLAQLSSGA SGFKRKVSTR
YPFHHPRMYI KDYFAVPPLE QKVVSVISNF PNPARQVTSC NAGAYIFHDG SDSNDMGAEA
FIHLLTQHGA SLRFASKEWV LNHYKWIVWK LACYERCYPA RCAGKFLTVS NVLEELKYRY
EREVNHGHRS TIKKILEGDG LPSSMMTLCI SSIHSDHVLD SGALSEPQTG NQSNEALKVE
LTDGWYSINA ILDVPLSKQL AAGRLFVGQK LRIWGAGLCG WNGPVSPLEV SSTVSLLLHI
NGTYRAHWAD RLGLCKVAGP PLAFKCIKRN GGLVPQTLAG ITRIYPILYK ERLSSGRSVV
ISERMENKMM ELHNQRRSAV VDNIVSEYQK EMTGSHIYDY GNSEGAKIYK MLETAAEPEF
LMADMTPEQL SSFAAYKAKL NANRQSQMES SIEKALKDSG LGDREVTPFM RLRVVGLTYK
NQRDKPTEGI VTIWNPTQKQ RQELSEGEAY AIAELIPSGS DSDVLHLQTR GSTTKWLPLS
SNAKEQFKPF SNNRNSIPLS SLSDIPLSNE FDVVAFVVHV GKVYTSSQQK KQWVFVTDGS
IMNGLQSQKV TDTLLAICFC SPLFDHDSFP PINHNLAGST VGFCNLIKKE KDHTNHIWVA
DANEISTYYL KFDSPQCSHL RNAASSVRRW ASNSSLIIEK LKEKVLGIVG DCKA
//
