ID G7JF29_MEDTR Unreviewed; 1157 AA.
AC G7JF29; A0A0C3X0X4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN OrderedLocusNames=MTR_4g081330 {ECO:0000313|EMBL:AES89895.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES89895.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES89895.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES89895.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES89895,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES89895.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES89895,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES89895}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES89895};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; CM001220; AES89895.2; -; Genomic_DNA.
DR RefSeq; XP_003607698.2; XM_003607650.2.
DR AlphaFoldDB; G7JF29; -.
DR PaxDb; 3880-AES89895; -.
DR EnsemblPlants; AES89895; AES89895; MTR_4g081330.
DR Gramene; AES89895; AES89895; MTR_4g081330.
DR eggNOG; ENOG502R41B; Eukaryota.
DR HOGENOM; CLU_001561_0_2_1; -.
DR Proteomes; UP000002051; Chromosome 4.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF259; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF101936; DNA-binding pseudobarrel domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 22..188
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1157 AA; 131884 MW; AFE8A3B2D40D936E CRC64;
MACTNKSIIQ SSNMVSDQSR KSSYDVFISF RGADTRFNFT DHLFSALQIR GIVAFRDDTK
LKKGESIAPE LLRAIEASRT FIVVFSNNYA SSTWCLRELQ YILHCVQLSG KRVLPVFYDV
DPSEVRKQSG SYKKAFAQHE ERFKQDTEVL QGWRTALTQV ANLSGWDIRD KPQSAEIKKI
VEEIVNILNC KFSSLPNDLV GTHSLIERLE KLLLLDVVDD VRIVGISGMG GVGKTTLARI
LYRRISSRFD ACCFIDDLSK ICKHAGPVAA QKQILSQTLG EEHLQICNLS DGANLIQNRL
GHLRAFIILD NVDQGEQLEK LALNRKLLGV GSRIIIISRD THILNRYGVD VVFKVPLLNQ
TNSLQLFCQQ AFKRDNILSN YDELVYEILN YANGLPLAIK ALGSFLFGRD IYEWRSALTR
LRDNPNKDIF DVLRLSFDGL ENMEKEIFLD IACFFNGRKE ALVKNVLNCC GFHADIGLRV
LIDKSLISIS EKSKIEMHGL LEELGKKIVQ ENSSKDSRKW TRLWLHEYFN NVMSENKEKN
VEAIVLRRGR QRETKIVIAE ALSKMSHLRM LILDGMDFSG SLDCISNELR YVEWREYPFM
YLPSSFQPYQ LVELILEDSS IKQLWEGTKY LPNLRTLELR NSKSLIKVPD FGEIPNLERL
NLKGCVKLEQ IDPSISVLRK LVYLNLEDCK NLVTIPNDLF GLTSLEYLNL SGCYKAFNTS
LHLKNYIDSS ESASHSQSKF SIFDWITLPL QSMFPKENLD MGLAIPSCLL PSLPSLSCLR
KLDISYCSLS QIPDAIGCLL WLERLNLGGN NFVTLPSFRE LSKLAYLNLE NCMQLKYFPE
LPSASSIEHE HSHMFSDTSY WRRAGLCIFN CPELGEMEKC SDLAFSWMIQ FLQANQLESS
SVFFREINIV IPGTEMPRWF NNQNMESSIS IDISPIMHHD SDVIAFACCV VFSAAPYPST
NMKTNYRKPV IHLCFSSGDL EVFLGIPAHT NLNMLKSNHI WLAYFTRESF IDLMSDIDST
LGDIRMEVLI VDGEGLDVEV KNCGYRWVYK HDLQHLNFTM MHCKSSLAQN CDILGIEDEA
QPELLLYESF CALTLGKKTA SVVLIDECGN KWNCITVFGK RPHRHIKIGG GWKRMVEARN
IPIGVSNEDR CSKGWEQ
//
