ID G7JKN3_MEDTR Unreviewed; 1088 AA.
AC G7JKN3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:AES86739.1};
GN OrderedLocusNames=MTR_4g014300 {ECO:0000313|EMBL:AES86739.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES86739.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES86739.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES86739.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES86739,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES86739.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES86739,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES86739}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES86739};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001220; AES86739.1; -; Genomic_DNA.
DR RefSeq; XP_003604542.1; XM_003604494.1.
DR AlphaFoldDB; G7JKN3; -.
DR PaxDb; 3880-AES86739; -.
DR EnsemblPlants; AES86739; AES86739; MTR_4g014300.
DR Gramene; AES86739; AES86739; MTR_4g014300.
DR eggNOG; ENOG502SUHE; Eukaryota.
DR HOGENOM; CLU_001561_0_0_1; -.
DR OMA; LANEIHW; -.
DR Proteomes; UP000002051; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF582; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 965..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..253
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1088 AA; 125379 MW; 9DF2E22AD118B42E CRC64;
MAYLSSGTSQ LIYARQYRHS GSKALQDGMI ARTYNSETRP FRASGTNHRI LKHQLNLWAI
PGVKKKEMVN KVVAKGVAEK AMSNDAPQLK YDVFVSFRGE DIRHGFLGHL IKAFPRKQIN
AFVDEKLKRG DDISHALVEA IEGSFISLVI FSENYASSHW CLEELVKIIE CKEKYGRIVL
PVFYGVDPTN VRHQKKSYKS AFSELEKRYH LSKVQNWRHA LNKSANLSGI KSLDFRNDAE
LLEEIINLVL KRLSKHPINT KGLIGIGKPV AHLESLLRQQ LEKVRVIGIW GMGGIGKTTI
AEEVFNRSCS EYEGFCFLEK VSEESGRHGI TFLKEKLFST LLAEDVKINS PNGLSNYIQR
MIGRMKVLIV LDDVKEEGQI EMLFGTLDWF RSDSRIILID IYEVGVLKPS EALELFHLNA
FKQSHLEMEY YELSKRVVAY AKGIPLGVKV LAHLLRGKVK EVWESQLDKL KKLPSKKVYD
VMRLSYDDLD RLEQKYFLDI TESDNSVVVG LERLKDKALI TISKYNVVSM HDILQEMGRE
VVRQESSEDP SKRSRLWDPD DICYVLKNDK GTDAIRSIRV DLSSFRKLKL SPHVFAKMTN
LRYLDFIGKY DLELLPQGLQ SFPTDLRYIC WIHYPLKSFP KKFSGKNLVI LDFSHSRVEN
LWCGVQDLVN LKEVRLTSSR FLKELPDFSK ATNLKVLNIT DCLSLESVHP SIFSLEKLVQ
LDLSHCFSLT TFTSNSHLSS LLYLNLGSCI SLRTFSVTTN NLIKLDLTDI GINELPSLFR
CQSKLEILVL RKSEIEIIPS SIQNLTRLRK LDIRYCLKLL ALPVLPLSVE TLLVECISLK
TVLFPSTISE QFKENKKRIE FWNCFNLDEH SLVNIGFNMK INLIKFAYQH LLTLEHDDYV
DSYADYEYNH SSYQALYVYP GSSVPEWLEY KTESNVREWL EYKTTEDDMI EAVFQSRWST
KQQRMTGLLI SLHIIFFFFC FILAEDYQHC AQIEFNITTI DDKDDDEKDG VSIYMNRTPL
SIASDHVCMI HNQQCSRYLT SVAKNHTRFK IKVTARTDTN VKLRERPEVE LKGFGISPIS
NSTYHNLI
//
