ID G7JSB5_MEDTR Unreviewed; 1684 AA.
AC G7JSB5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:AES87054.1};
DE SubName: Full=Putative TIR domain, winged helix-turn-helix DNA-binding domain-containing protein {ECO:0000313|EMBL:RHN59047.1};
GN Name=11413079 {ECO:0000313|EnsemblPlants:AES87054};
GN OrderedLocusNames=MTR_4g020590 {ECO:0000313|EMBL:AES87054.1};
GN ORFNames=MtrunA17_Chr4g0009041 {ECO:0000313|EMBL:RHN59047.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES87054.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES87054.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES87054.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES87054,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES87054.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES87054,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES87054}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES87054};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5] {ECO:0000313|EMBL:RHN59047.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN59047.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001220; AES87054.1; -; Genomic_DNA.
DR EMBL; PSQE01000004; RHN59047.1; -; Genomic_DNA.
DR RefSeq; XP_003604857.1; XM_003604809.2.
DR PaxDb; 3880-AES87054; -.
DR EnsemblPlants; AES87054; AES87054; MTR_4g020590.
DR GeneID; 11413079; -.
DR Gramene; AES87054; AES87054; MTR_4g020590.
DR KEGG; mtr:11413079; -.
DR eggNOG; ENOG502QQJE; Eukaryota.
DR OrthoDB; 1222225at2759; -.
DR Proteomes; UP000002051; Chromosome 4.
DR Proteomes; UP000265566; Chromosome 4.
DR ExpressionAtlas; G7JSB5; differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF271; NBS-LRR DISEASE RESISTANCE PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00255; TIR; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000313|EMBL:RHN59047.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 25..154
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 512..675
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1684 AA; 190885 MW; 25D1C0EED5160DB7 CRC64;
MSSFTSSSKI CQEFESILTT DPKKRRYNVF LSFCAHDKGY FLSSLEEALS LEAGINVFGD
IKRFQHVESV LNVIQDCKVA VVLFSKNYTN SSSCIQELEK ITQCCRTSDL VVLPVFYQGV
GPFYHGDMFG GDTFHDFLDR ISMEEISKEE DKLMTWVAAI TKANKYLGSR DLIPKPIYRY
EHVSITDYIK DIVEHITCVI NKNRDFCANS CTPSVKSGVQ DVIQLLKQSK SPLIIGIWGM
TGIGKSTIAQ AIYDQIGLYF EHKSFLKDLG VLWEEQNHDQ VLFKGHQHHR VLLVLDNIDK
LEQLDVLGLR RSRKWFGEGS KIIITTRDRH LLKKHGIDHI YRVKELDESE SLKVFNLAAF
SQATTPQEDF SELSRQLVAY SRGLPLALKE LGFFLNGEEA LKWKNVLKSL KRLSIPAPRL
QEALEKSFSD LSDEEKRIFL DIACLFVGMN LNDVKQILNR STQSAALEIS NLEDKSFLTI
DENNKLGIHV LLQAMARDII KRKSSNNTDQ PKMYDVFLSF RGEDNRAKFM SHLYSSLQNA
GIYVFRDDDE IQRGDHISIS LLRAIEQSRT CIVVLSTNYA NSRWCMLELE KIMEIGRNRG
LVVVPVFYEV APSEVRHQEG QFGKSFDDLI SKNSVDESTK SNWKRELFDI GGIAGFVLID
SRNESADIKN IVEHITRLLD RTELFVAEHP VGVESRVEAV TKLLNIQNSD DVLILGIWGM
GGMGKTTLAK AIYNQIGSKF EGRSFLLNIR ELWETDTNQV SLQQKILDDV YKTLTFKIRD
LESGKNMLKE KLSQNRVLLV FDDVNELEQL KALCGSRDWF GPGSRIIITT RDMHLLRLCG
VYQMYTIEEM DKIESLKLFS WHAFKQPSPK EDFATHSTDV IAYSGGLPLA LEVLGSYLAD
CEITEWQYVL EKLKCIPHDQ VQEKLKVSFH GLKDFTEKQI FLDIACFFIG MDKKDVIQIL
NGCGFFADIG IKVLVERALV TVDNRNKLRM HDLLRDMGRQ IIYEEAPSDP EKRSRLWRHG
EVFDILEKRK GTEAVKGLAL EFPRKDCLET KAFKKMNKLR LLRLAGVKLK GDFKYLSGDL
KWLYWHGFAE PCFPAEFQQG SLVSVELKYS RLKQLWNKCQ MLENLKILNL SHSLDLTETP
DFSYLPNLEK LVLKNCPSLS TVSHSIGSLH KLILINLRGC TGLRKLPRSI YKLKSLETLI
LSGCSMIEKL EEDLEQMESL ITLIADKTAI TKVPFSIVRM KSIGYISFCG FEGFSRDVFP
SLIRSWMSPS NNVISLVQTS VSMSSLGTSK DLQKLRILCV ECGSDLQLTQ DIVRFLGVLK
ATSYQKLEAS AISIPSEISD MYASPLIDDF LGKVCTSGSM NHLKSLLIQM GTKCQVSDIA
VDVLQTADET WDSFFLPCDN NSEWSSFSCK GCSIIFDIPT IKGRNLKSMI LFVVYYSSSE
NITSDSCQGV LIINYTKRTI QVYKRDTLTS FEDEDWQSIT SNLEPGNKVE VMVVFGEGFI
VEKTTISLLY DEPVNKEMEC CHVVDVDDVI VSGNDDNNVG VSSGDNEVIN QFGEETPNHL
QIISPADGWY ADVVGPVLLV PYDLHQLAEA EAEELHAAEE KHDQEQQVLP LKCEPEQHAI
VASATIEPTL GAQILDAIRE LRADFIRQEL TVTARLNAVD VRLERLEDGI AHILHGSSFE
STHS
//
