ID G7K336_MEDTR Unreviewed; 871 AA.
AC G7K336; A0A0C3XT69;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=GTPase-activator protein for Rho-like GTPase family protein {ECO:0000313|EMBL:AET00208.2};
DE SubName: Full=Putative Rho GTPase activation protein {ECO:0000313|EMBL:RHN57563.1};
GN Name=11431858 {ECO:0000313|EnsemblPlants:AET00208};
GN OrderedLocusNames=MTR_5g089490 {ECO:0000313|EMBL:AET00208.2};
GN ORFNames=MtrunA17_Chr5g0441801 {ECO:0000313|EMBL:RHN57563.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AET00208.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AET00208.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AET00208.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AET00208,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AET00208.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AET00208,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AET00208}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AET00208};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5] {ECO:0000313|EMBL:RHN57563.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN57563.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001221; AET00208.2; -; Genomic_DNA.
DR EMBL; PSQE01000005; RHN57563.1; -; Genomic_DNA.
DR RefSeq; XP_003617249.2; XM_003617201.2.
DR AlphaFoldDB; G7K336; -.
DR PaxDb; 3880-AET00208; -.
DR EnsemblPlants; AET00208; AET00208; MTR_5g089490.
DR Gramene; AET00208; AET00208; MTR_5g089490.
DR eggNOG; KOG4271; Eukaryota.
DR HOGENOM; CLU_011283_1_0_1; -.
DR Proteomes; UP000002051; Chromosome 5.
DR Proteomes; UP000265566; Chromosome 5.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00821; PH; 1.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR025757; MIP1_Leuzipper.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46265; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR46265:SF2; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR Pfam; PF14389; Lzipper-MIP1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 18..125
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 172..372
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 383..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 604..638
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 663..697
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 825..852
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 455..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 96175 MW; C71094BBB0A0619D CRC64;
MSASLAAFER PRPGASNTVF KSGPLFISSK GIGWKSWKKR WFILTRTSLV FFKNDPSTLP
QRGGEVNMTL GGIDLNNSGS VVVREDKKLL TVLFPDGRDG RAFTLKAETS EDLFEWKTAL
EQALAQAPSA ALVMGHNGIF RNDTTDSIDG SFHQWRDKRP VKSLVVGRPI LLALEDIDGG
PSFLEKALRF LEKHGTKVEG ILRQSADVEE VDRRVQEYEQ GKVEFDAEED AHVVGDCVKH
VLRELPSSPV PASCCTALLE AYRIDRKEAR INAMRCAILE TFPEPNRRLL QRILKMMHTI
ASHSNVNRMT ASAVAACMAP LLLRPLLAGE CELEDEFDVS GDSSAQLLAA ANAANNAQAI
ITTLLEEYEN VFDEENIQRC SISADSRVEN SGSEDSTDDD NIDVKENGYH DAENENDQET
DDDADRVHSG KLSESSGYAG SDLYDYKAFG GDDSDVGSST SNHAQAENSN LNTVPDTHLS
EDKSKQRKVN ENVVDDDPPI VLPSTESYRS MGEILSSMDP GNHLPVIEAQ SGTGKQTTGK
TSSGTSFSTK RSTFWGRSNP RKSPSVESVD SSGEEELAIQ RLEIAKNDLQ HRIAKEARGN
AILQASLERR KQALHERRLA LEQDVSRLQE QLQAERDLRA ALEVGLSMSS GQISNSRGMD
SKTKAELEEI ALAEADVARL KQKVAELHHQ LNQQRQHHYG SVTDVGDRYQ HAQNLPQPRF
LQQDFDSTLA YCNHERKQRT EESGLGSDWR NIKGQVLASG NGSRQPSRKP FIDSSPSDSK
STEASTSMSV DELGVVDSGS VPSTSRAAEV TEYNGRHPSV ASSTLVELTT RLDFFKERRS
QLMEQLHNLD LNYGSTTSQD MVYKPTSPSW S
//
