ID G7K9Q6_MEDTR Unreviewed; 1056 AA.
AC G7K9Q6; A0A0C3XHP2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 08-NOV-2023, entry version 58.
DE SubName: Full=Disease resistance protein {ECO:0000313|EMBL:AES96527.2};
GN Name=11414724 {ECO:0000313|EnsemblPlants:AES96527};
GN OrderedLocusNames=MTR_5g038180 {ECO:0000313|EMBL:AES96527.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES96527.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES96527.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES96527.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES96527,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES96527.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES96527,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES96527}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES96527};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001221; AES96527.2; -; Genomic_DNA.
DR RefSeq; XP_003613569.2; XM_003613521.2.
DR AlphaFoldDB; G7K9Q6; -.
DR PaxDb; 3880-AES96527; -.
DR EnsemblPlants; AES96527; AES96527; MTR_5g038180.
DR GeneID; 11414724; -.
DR Gramene; AES96527; AES96527; MTR_5g038180.
DR KEGG; mtr:11414724; -.
DR eggNOG; ENOG502QQJE; Eukaryota.
DR HOGENOM; CLU_001561_5_1_1; -.
DR Proteomes; UP000002051; Chromosome 5.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF219; ARCHAEAL ATPASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 20..195
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1056 AA; 121238 MW; 0C763F7ECB4D286C CRC64;
MAFQSFPSSF SSSSSFSYGF NYDVFLNFCG DDTRFHFTGN LYKALCDKGI RVFIDDKELQ
RGDKITPSLI KAIEDSRIAI PVFSKNYAFS SFCLDELVNI IDGFSAKGRL VLPVFYDVDP
SHVRHQIGSY GEAIAMHEAR LKRDKEMYID NMDRLQKWKT ALNQAANLSG YHFNHGNEYE
HEFIGRIMKE VAKKINRDLL HVADYAVGLE SRLLQVNSLL SVESNNGVYM VGIHGIGGIG
KTTLARAIYN LIADQFECLC FLHDVRENSS KHGLEHLQER LLSKTIGLDI KLGHVSEGIP
IIKQRLQQKK VLLILDDVDE QKQLQVMVGE PDWFGPGSRV IITTRDKHLL TSHGIDRIYE
VDGLNGEEAL ELLRWKTFKN NKVDSSFEYI LKYVVTYASG LPLALEVVGS NLFGKNIEEW
KSTFDRYEWI PGKRIHKILK VSFDSLEEDE KSVFLDIACC FKGYDLTEVE FILCAHYGKC
IKYHIGVLVE KSLIKINQWG YVTLHHLIED MGKEIVRKES PKHPGKRSRL WFHEDIVQVL
EENMGTTEIE IVYLDFPLFE EVVEWKGDEF KKMINLKTLI IKNGHFSKGP KHLPNSLRVL
EWHRYPSLSI PSNFYQKKLS ICKLGESFFT TFELHGSLKK FVNMRELNLD NCKYLTHIFD
VSCLPNLEKI SFRHCENLMT IDSSVGFLNK LKIIRADGCL KLMSFPPMEL TSLQRLELSF
CDSLECFPEI LGEMENITEI VLEGTSIEEL SYSFQNLTGL RKLQIRRSGV LRLPSNILMM
PKLSYILVEG ILLLPNKNDN LSSSTSSNVE ILRLPNCNLS DEFLQTSLAW FANVIHLDLS
RNSFTILPEF IKECHFLITL NLNDCTCLRE IRGIPPNLKR LSALQCESLS SSCRSMLLNQ
ELHEAGSTDF CLPGTSPIPE WFQHQTRGSS ISFWFRNNVP SVSLFVALKP MRNECINYGF
LPLATINLTI NGHKFDLRCP PDGIRLMMSL GHTYLSDMQL HEMDLESKLE EELLRNEWVH
VEVLFKHQMK KTLLIESGIH LFKQKSSMED IQFNNP
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