ID G7KE95_MEDTR Unreviewed; 1016 AA.
AC G7KE95;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Disease resistance protein RGA4 {ECO:0000313|EMBL:AES98639.1};
DE SubName: Full=Putative P-loop containing nucleoside triphosphate hydrolase, leucine-rich repeat domain, L {ECO:0000313|EMBL:RHN56500.1};
GN Name=11413502 {ECO:0000313|EnsemblPlants:AES98639};
GN OrderedLocusNames=MTR_5g070960 {ECO:0000313|EMBL:AES98639.1};
GN ORFNames=MtrunA17_Chr5g0430141 {ECO:0000313|EMBL:RHN56500.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AES98639.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AES98639.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AES98639.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AES98639,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AES98639.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES98639,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AES98639}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AES98639};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN56500.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN56500.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001221; AES98639.1; -; Genomic_DNA.
DR EMBL; PSQE01000005; RHN56500.1; -; Genomic_DNA.
DR RefSeq; XP_003615681.1; XM_003615633.2.
DR AlphaFoldDB; G7KE95; -.
DR STRING; 3880.G7KE95; -.
DR PaxDb; 3880-AES98639; -.
DR EnsemblPlants; AES98639; AES98639; MTR_5g070960.
DR Gramene; AES98639; AES98639; MTR_5g070960.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_8_8_1; -.
DR OMA; FIQDCEM; -.
DR OrthoDB; 643105at2759; -.
DR Proteomes; UP000002051; Chromosome 5.
DR Proteomes; UP000265566; Chromosome 5.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF33; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:RHN56500.1};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 6..100
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 158..406
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1016 AA; 116074 MW; C89F658AD34B430A CRC64;
MADALLGVVF ENLTALLQNE FSTISGIKSK VQKLSNNLVH IKAVLEDAEK KQFKELSIKL
WLQDLKDGVY VLDDILDEYS IKSCRLRGFT SFKPKNIMFR HEIGNRFKEI TRRLDDIAES
KNKFSLQMGG TLREIPDQVA EGRQTGSIIA EPKVFGREVD KEKIVEFLLT QARDSDFLSV
YPIVGLGGVG KTTLVQLVYN DVRVSGNFEK KIWVCVSETF SVKRILCSII ESITLQKCPD
FDYAVMEREV QGLLQGKRYL LVLDDVWNQN QQLESGLTRE KWNKLKPVLS CGSKGSSILV
STRDEVVATI TGTYQTHHRL SSLSDSECWL LFEQYAFGHH KEERADLVAI GKEIVKKCNG
LPLAAKSLGS LMNSRKDEKE WLKIKDSELW DLSDENSILP ALRLSYFYLP AALKQCFSFC
AIFPKDAEIL KEELIWLWMA NGLISSRGTT EVEDVGIMVW DELYQKSFFQ DRKMDEFSGD
ISFKMHDLVH DLAQSVMGQE CMYLENANLT SLSKSTHHIS FDNKDSLSFD KDAFKIVESL
RTWFEFCSTF SKEKHDYFPT NLSLRVLCIT FIREPLLGSL IHLRYLELRS LDIKKLPDSI
YNLQKLEILK IKDCRKLSCL PKRLACLQNL RHIVIEVCRS LSLMFPNIGK LTCLRTLSVY
IVSLEKGNSL TELRDLNLGG KLHIQGLNNV GRLFEAEAAN LMGKKDLHEL YLSWKDKQGI
PKNPVVSVEQ VLEVLQPHSN LNCLKISFYE GLSLPSWIII LSNLVSLKLK RCKKVVRLQL
LGILPSLKNL ELSYMDNLKY LDDDESEDGM EVRVFPSLEE LVLYQLPNIE GLLKVERGEM
FPCLSKLDIS ECRKLGLPCL PSLKSLTVSE CNNELLRSIS TFRGLTQLFV NGGEGITSFP
EGMFKNLTSL QSLRIYNFPK LKELPNETFN PALTLLCICY CNELESLPEQ NWEGLQSLRT
LHIYSCEGLR CLPEGIRHLT SLELLTIIGC RTLKERCKKR TGEDWDKISH IPKIQF
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