ID G7L6S8_MEDTR Unreviewed; 1059 AA.
AC G7L6S8; A0A0C3XXJ3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:AET01732.2};
GN OrderedLocusNames=MTR_8g020360 {ECO:0000313|EMBL:AET01732.2};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AET01732.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AET01732.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AET01732.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AET01732,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AET01732.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AET01732,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AET01732}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AET01732};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001224; AET01732.2; -; Genomic_DNA.
DR RefSeq; XP_003627256.2; XM_003627208.2.
DR AlphaFoldDB; G7L6S8; -.
DR PaxDb; 3880-AET01732; -.
DR EnsemblPlants; AET01732; AET01732; MTR_8g020360.
DR Gramene; AET01732; AET01732; MTR_8g020360.
DR eggNOG; ENOG502QQJE; Eukaryota.
DR HOGENOM; CLU_001561_0_0_1; -.
DR Proteomes; UP000002051; Chromosome 8.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF398; RESISTANCE PROTEIN (TIR-NBS-LRR CLASS), PUTATIVE-RELATED; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1059
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014574072"
FT DOMAIN 48..211
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1059 AA; 121117 MW; EFD430D2449EBEE3 CRC64;
MKICESSSSI SLFLYLTLLL ILKPRGVVPN PISNKIFSPS TSIPAPQIKY DVFVSFRGSD
IRKNFLSHVL DALSRKGIIV FSDKKLITGD ELSAIQRAIE KSLISLVIFS PNFASSHWCL
DELVKIVECR ANYGRVLMPV FYQVYPSDVR HQNGTYRDAF AQHEQKYSSY KVLSWRSALK
QSANMSGFDS SLFSDDAKLV EEIVQNVLIK LNQVDQGKSK GLVGIEKKIS PIESLLHLES
EDVRVLGIWG MPGIGKTTIA EEVFRRLRSK YESCYFMANV REESERCGTN SLRLRKIILS
TLLKEENLKD ELINGLPPLV KKRLHRMKVL IVLDDIKDAE QLEVLIGTVD WLGPRSRIII
TTRDKQVLAG KVDDIYEVEP LDSAESFQLF NLHAFTKHEH LEMEYYELSK KMVDYTAGVP
LVLKALANLL CGKDKDIWES QAKILKIEQI ENVHVVFRLI YTNLDSHEKN ILLDIACFFD
GLKLKLDLIK LLLKDRHYSV STKLDRLKDK ALVTISQQSI VSMHDIIQET AWEIVRQESV
EEPGSRSRLL NPDDIYHVLK DDKGGEAIRS MAIRLSEIKE LHLSPRVFAK MSKLKFLDIY
TNGSQNEGRL SLPRGLEFLP NELRYLRWEY YPLESLPSKF SAENLVRLSL PYSRLKKLWN
GVKDIVNLNV LILSSSTFLT ELPDFSKAAS LEVINLRLCL KELDLSGCIS LTSLQSNDTH
LSSLRYLSLY NCTSVKEFSV TSKHMNILDL EGTSIKNLPS SIGLQTKLEK LYLAHTHIQS
LPKSIRNLTR LRHLDLHLCS ELQTLPELAQ SLEILDACGC LSLENVAFRS TASEQLKEKR
KRVIFWNCLK LNEPSLKAIE LNAQINMMSF SYQHISTWDR DHDHNHNHNH SIYVYPGSEI
PEWLEYSTTT HDYITIDLSS APYFSKLGFI FGFIIPTNSS EGQIVKLKIS DGQDKGIKMY
LSRPRRGIES DHVYLMYDRR CSHYLASRVN DQSKIKIQVR ASLKTPTLQY VPVQLRGFGV
SLVTPSKYDK FKQQLEFRDR SVVPINMCPV EEISKFLGI
//