ID G7LDV9_MEDTR Unreviewed; 883 AA.
AC G7LDV9; A0A0C3Y3N1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:AET03874.2};
DE SubName: Full=Putative TIR domain, P-loop containing nucleoside triphosphate hydrolase {ECO:0000313|EMBL:RHN42054.1};
GN Name=11408172 {ECO:0000313|EnsemblPlants:AET03874};
GN OrderedLocusNames=MTR_8g076910 {ECO:0000313|EMBL:AET03874.2};
GN ORFNames=MtrunA17_Chr8g0372681 {ECO:0000313|EMBL:RHN42054.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:AET03874.2, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:AET03874.2, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:AET03874.2}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:AET03874,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:AET03874.2, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AET03874,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:AET03874}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:AET03874};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN42054.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN42054.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001224; AET03874.2; -; Genomic_DNA.
DR EMBL; PSQE01000008; RHN42054.1; -; Genomic_DNA.
DR RefSeq; XP_003629398.2; XM_003629350.2.
DR AlphaFoldDB; G7LDV9; -.
DR PaxDb; 3880-AET03874; -.
DR EnsemblPlants; AET03874; AET03874; MTR_8g076910.
DR GeneID; 11408172; -.
DR Gramene; AET03874; AET03874; MTR_8g076910.
DR KEGG; mtr:11408172; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_0_1; -.
DR OrthoDB; 953074at2759; -.
DR Proteomes; UP000002051; Chromosome 8.
DR Proteomes; UP000265566; Chromosome 8.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF512; RESISTANCE PROTEIN (TIR-NBS-LRR CLASS), PUTATIVE-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:RHN42054.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 14..179
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 883 AA; 100481 MW; 17BC7A86B88B5D26 CRC64;
MAPSSFSSHA VALKKYDVFI SFRGEDTRAG FTSHLYETFL QSKFHTYIDY RIQKGDHVWA
ELTKAIKQST IFLVVFSKNY ASSTWCLNEL VEIMECSNKD NVAVIPVFYH IDPSRVRKQT
GSYGTALAKH KKQGCDHKMM QNWKNALFQA ANLSGFHSTT YRTESDLIED ITRVVLRKLN
HKYTNELTCN FILDENYRTI QSLIKKIDSI EVQIIGLWGM GGIGKTTLAA ALFQRVSFKY
EGSCFLENVT EVSKRHGINF ICNKLLSKLL REDLDIESAK VIPSMIMRRL KRMKSFIVLD
DVHTLELLQN LIGVGNGWLG DGSIVIVTTR DKHVLVSGGI DKIHQVKEMN SRNSLQLFSF
NAFDKVLPKE GYVELSERVI DYAKGNPLAL KVLGSFLCSK SEIEWNCALA KLKEIPNAEI
DKIMRWSYNE LDDKEKNIFL DIACFFKGHE RDRMTTILNQ CGFFADIGIR TLLDKALIRV
DFENCIQMHD LIQEMGKQVV REESLKNPEQ SSRLWDPKEV YDVLKNNRET KIVEAIFLDA
TESRHINLSP KTFEKMPNLR LLAFRDHKGI KSVSLPSGLD SLPKNLRYFL WDGYPSKSLP
PTFCPEMLVE FSLQDSHVEN LWNGELNLPN LEILDLSNSK KLIECPNVSG SLNLKYVRLN
GCLSLPEVDS SIFFLQKLES LIIDGCISLK SISSNTCSPA LRELNAMNCI NLQEFSVTFS
SVDNLFLSLP EFGANKFPSS ILHTKNLEYF LSPISDSLVD LPENFANCIW LANSLKGERD
SSIILHKILP SPAFLSVKHL ILFGNDVPFL SEIPDNISLL SSLKSLRLFN IAIRSLPETI
MYLPQLESLS VFNCKMLLFR LFQSSFHFSL SGIVNLLRKC CVQ
//
