ID G7LPJ5_9GAMM Unreviewed; 408 AA.
AC G7LPJ5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Beta-ketoacyl-acyl-carrier-protein synthase I {ECO:0000313|EMBL:EHD23782.1};
DE EC=2.3.1.41 {ECO:0000313|EMBL:EHD23782.1};
GN ORFNames=BrE312_4467 {ECO:0000313|EMBL:EHD23782.1};
OS Brenneria sp. EniD312.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Brenneria.
OX NCBI_TaxID=598467 {ECO:0000313|EMBL:EHD23782.1};
RN [1] {ECO:0000313|EMBL:EHD23782.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EniD312 {ECO:0000313|EMBL:EHD23782.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Monk A.C., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Balakrishnan V.,
RA Glasner J., Perna N., Woyke T.;
RT "Complete sequence of Brenneria sp. EniD312.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CM001230; EHD23782.1; -; Genomic_DNA.
DR RefSeq; WP_009115076.1; NZ_CM001230.1.
DR AlphaFoldDB; G7LPJ5; -.
DR STRING; 598467.BrE312_4467; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_6; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000002759; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF325; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE II FABF; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:EHD23782.1};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:EHD23782.1}.
FT DOMAIN 1..406
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 408 AA; 43750 MW; 0B49DA895586E4CB CRC64;
MRRVVVTGMG GVTAFGESWQ RVSDGLRAGR NAIRKMPEWG VYDGLNTQLG SPIDDFTLPE
HYTRKRIRSM GRVSLMATRA TELALQQAGL LEHPVLTSGE TGIAYGSSTG STGPVSDFAT
MLTEKHTNNI TGTTYVQMMP HTTAVNAGLF FGLRGRVIPT SSACTSGSQA IGYAWEAIRH
GYQTVMVAGG AEELCPSEAA VFDTLFATSQ RNDAPHTTPS PFDAGRDGLV IGEGAGTLVL
EELEHAQARG ATIYAELVGF FTNCDAAHIT QPQRETMQIC IEGSLRCAGL SAGDIGYINA
HGTATDRGDV AESLATAAVF GDATPISSLK SYFGHTLGAC GALEAWMSIE MMREGWFAPT
LNLRQPAQDC GALDYIMGEP RYIDTDYVQS NNFAFGGINT SLIFRRWK
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