ID   G7LR26_9GAMM            Unreviewed;       169 AA.
AC   G7LR26;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Leucine-responsive regulatory protein {ECO:0000256|ARBA:ARBA00039227};
GN   ORFNames=BrE312_4485 {ECO:0000313|EMBL:EHD23800.1};
OS   Brenneria sp. EniD312.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Brenneria.
OX   NCBI_TaxID=598467 {ECO:0000313|EMBL:EHD23800.1};
RN   [1] {ECO:0000313|EMBL:EHD23800.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EniD312 {ECO:0000313|EMBL:EHD23800.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Monk A.C., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Balakrishnan V.,
RA   Glasner J., Perna N., Woyke T.;
RT   "Complete sequence of Brenneria sp. EniD312.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp mediates
CC       this effect for at least some of these operons. For example it is
CC       regulator of the branched-chain amino acid transport genes.
CC       {ECO:0000256|ARBA:ARBA00037041}.
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DR   EMBL; CM001230; EHD23800.1; -; Genomic_DNA.
DR   RefSeq; WP_009115094.1; NZ_CM001230.1.
DR   AlphaFoldDB; G7LR26; -.
DR   STRING; 598467.BrE312_4485; -.
DR   eggNOG; COG1522; Bacteria.
DR   HOGENOM; CLU_091233_0_0_6; -.
DR   Proteomes; UP000002759; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 3.30.70.920; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR30154:SF0; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   Pfam; PF13404; HTH_AsnC-type; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          20..83
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50956"
SQ   SEQUENCE   169 AA;  18859 MW;  1147062EE56CDF85 CRC64;
     MKAKSPIVTP PAEEKKSYEL DRFDTAILRL LQADASLSNV ALAEKVNLSP PACLRRVERL
     KQIGLIKHLV ALLDPQALNA GLVVLIGVVL DRSTPSSFED FEASVQRISG CMECHVVTGE
     FDYILKIRTK DNQSFNRLHA EQLLFLPGVR QIRSFIGLRE VLSTTQLTF
//