ID G7LT99_9GAMM Unreviewed; 345 AA.
AC G7LT99;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Glutathione import ATP-binding protein GsiA {ECO:0000256|ARBA:ARBA00041187};
DE EC=7.4.2.10 {ECO:0000256|ARBA:ARBA00039050};
GN ORFNames=BrE312_1217 {ECO:0000313|EMBL:EHD20637.1};
OS Brenneria sp. EniD312.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Brenneria.
OX NCBI_TaxID=598467 {ECO:0000313|EMBL:EHD20637.1};
RN [1] {ECO:0000313|EMBL:EHD20637.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EniD312 {ECO:0000313|EMBL:EHD20637.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Monk A.C., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Balakrishnan V.,
RA Glasner J., Perna N., Woyke T.;
RT "Complete sequence of Brenneria sp. EniD312.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex GsiABCD involved in
CC glutathione import. Responsible for energy coupling to the transport
CC system. {ECO:0000256|ARBA:ARBA00037530}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:29791, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; EC=7.4.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00036581};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GsiA),
CC two transmembrane proteins (GsiC and GsiD) and a solute-binding protein
CC (GsiB). {ECO:0000256|ARBA:ARBA00011469}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Glutathione
CC importer (TC 3.A.1.5.11) family. {ECO:0000256|ARBA:ARBA00038416}.
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DR EMBL; CM001230; EHD20637.1; -; Genomic_DNA.
DR RefSeq; WP_009111943.1; NZ_CM001230.1.
DR AlphaFoldDB; G7LT99; -.
DR STRING; 598467.BrE312_1217; -.
DR eggNOG; COG4608; Bacteria.
DR HOGENOM; CLU_000604_1_23_6; -.
DR Proteomes; UP000002759; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015833; P:peptide transport; IEA:InterPro.
DR CDD; cd03257; ABC_NikE_OppD_transporters; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013563; Oligopep_ABC_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01727; oligo_HPY; 1.
DR PANTHER; PTHR43776:SF15; GLUTATHIONE IMPORT ATP-BINDING PROTEIN GSIA; 1.
DR PANTHER; PTHR43776; TRANSPORT ATP-BINDING PROTEIN; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF08352; oligo_HPY; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:EHD20637.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 14..261
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 267..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 37343 MW; 256D5908E98D39D3 CRC64;
MDNHDIGGPA QPLLMGQKLV KHFPVKGVLG KRALVRAVDG IDFAVLKGET LGVVGESGCG
KSTTARVLMQ LIEQDGGELI FDGQSVGSQP LPLRRYRRQV QMVFQDSYSS LNPRLTMEQS
VAFGPLVHGT GKREAGERAR DLMARVGLEP ARFAGRYAHE LSGGQRQRVN IARALAVDPR
LVILDEAVSA LDKSVEAQVI NLLLDLKESL NLTYVFISHD LHVVRYLSDR IMVMYLGEVV
EIGPAEALFS GALHPYTRAL LSSMPSMDPA RRTLSSPLSG DPPSPIDPPA GCRFHTRCPH
AEAVCGQRKP RLYSASARHS AACLMVEPGG GHSQSPASPI FVKEA
//
