ID G7M307_9CLOT Unreviewed; 665 AA.
AC G7M307;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=CDLVIII_3238 {ECO:0000313|EMBL:EHI99811.1};
OS Clostridium sp. DL-VIII.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=641107 {ECO:0000313|EMBL:EHI99811.1, ECO:0000313|Proteomes:UP000005106};
RN [1] {ECO:0000313|EMBL:EHI99811.1, ECO:0000313|Proteomes:UP000005106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DL-VIII {ECO:0000313|EMBL:EHI99811.1,
RC ECO:0000313|Proteomes:UP000005106};
RX PubMed=23929491;
RA Taghavi S., Izquierdo J.A., van der Lelie D.;
RT "Complete Genome Sequence of Clostridium sp. Strain DL-VIII, a Novel
RT Solventogenic Clostridium Species Isolated from Anaerobic Sludge.";
RL Genome Announc. 1:e00605-e00613(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CM001240; EHI99811.1; -; Genomic_DNA.
DR RefSeq; WP_009170473.1; NZ_CM001240.1.
DR AlphaFoldDB; G7M307; -.
DR STRING; 641107.CDLVIII_3238; -.
DR eggNOG; COG5002; Bacteria.
DR HOGENOM; CLU_000445_89_20_9; -.
DR Proteomes; UP000005106; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR033425; MASE3.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF17159; MASE3; 1.
DR Pfam; PF13188; PAS_8; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EHI99811.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005106};
KW Transferase {ECO:0000313|EMBL:EHI99811.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 414..635
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 665 AA; 77084 MW; DDA76D2F1AEA373C CRC64;
MYNLSINQKK LIEFFILAFL FLSLNFIGKQ NYILFNNIIE IMTVILGFTL IVVSINTIKT
GENNYFHILA IIFGFGSIIN LFYILLSGYY NIGIQLNIFD EYYECVMLII SFNYINKKIY
WHKMLYLHII IAIFIVLGII GFNFIIISSM DKYFLTLFYQ ISKGLLAICF TVTLLGIMKC
KVNVLNNNKY GLLMAVVFEI LSCISFVIYG NVYGAGNILG NLFKLIACYY AFKATLKGIV
IDTYTNLFQK FENKAYELEN VNEKLYEANH KIQNIEKLNE RFINLIPDGL LIVRDRKIES
ANKRFLDMLE IDNENELKNK LFIEILDKQY HGIFLNRINS PDKGVLERQQ EYEFVWKNRK
KWVETTSLIV NDEDGEYIIS AIRNIEDRKK AEEAVQLLEL KRKEENMKND FFANISHELR
TPINVIYSAL QVENNYLEDD SAKKLILKYN KIIRQNCLRL MRLINNIIDI TKIETSFFKP
NCKIENIVSV VEDITMSIIE YAESKKIKLI FDTEVEEAYV SCDSDLIERI MLNLLSNAVK
YGKENGGIEV YICKSSENSI SISVKDDGIG IPDEMKVKIF DRFLKVDNSL SRRTEGSGIG
LSLVKQLVEI HKGTITCNSK LNEGSEFEVI FPTVEYSINT PNTEEINQPK NAIKPTEIEF
SDIYY
//
