ID G7M5A2_9CLOT Unreviewed; 618 AA.
AC G7M5A2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Integral membrane sensor signal transduction histidine kinase {ECO:0000313|EMBL:EHI99705.1};
GN ORFNames=CDLVIII_3123 {ECO:0000313|EMBL:EHI99705.1};
OS Clostridium sp. DL-VIII.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=641107 {ECO:0000313|EMBL:EHI99705.1, ECO:0000313|Proteomes:UP000005106};
RN [1] {ECO:0000313|EMBL:EHI99705.1, ECO:0000313|Proteomes:UP000005106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DL-VIII {ECO:0000313|EMBL:EHI99705.1,
RC ECO:0000313|Proteomes:UP000005106};
RX PubMed=23929491;
RA Taghavi S., Izquierdo J.A., van der Lelie D.;
RT "Complete Genome Sequence of Clostridium sp. Strain DL-VIII, a Novel
RT Solventogenic Clostridium Species Isolated from Anaerobic Sludge.";
RL Genome Announc. 1:e00605-e00613(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM001240; EHI99705.1; -; Genomic_DNA.
DR AlphaFoldDB; G7M5A2; -.
DR STRING; 641107.CDLVIII_3123; -.
DR eggNOG; COG2972; Bacteria.
DR HOGENOM; CLU_020473_6_1_9; -.
DR Proteomes; UP000005106; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000313|EMBL:EHI99705.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005106};
KW Transferase {ECO:0000313|EMBL:EHI99705.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 508..615
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 618 AA; 70264 MW; 83FABC97BED9C041 CRC64;
MNFTINVEFE FMGCIGMLIK KLNKKLSDGK IGLIIALFYF VLIVASTFVS SFFYEKIYLN
ITQKKVSEVS VQTLNSIQTN INLMINNADS LSKMVLSNSD LQKLLRQGGM YEDLNAQAKV
SSYLYKFIQS VPYVSSVYIL DNSSNVYSVG ADVLPSLSAY KIINAEWYKR VMEKNGGFIL
ELNGGGVTFE NSQDNYVSLI RLVRDMDNVD KLGVLVINIP QKSFKQVFDN ISSDVETNIT
VLDEKNQKIT SLKSVNNKEG SVQGNINIDN EMIRAGDEFV GKDIGYKMKK IDKTEYLISY
SSKNDYNWKF VSVIPFTKLY KENMTMIFIG FIVILFNGII LFVCSIGISR IFTMPIGYLL
NSMKDIEKGV FNEVHIKAYG YELKKLCSGY NIMIAEIKKL IVHVIEEQKT IRKAELYTFQ
AQIKPHFLYN TLDSINSLAL SGCNKEVSEL VEALGNYYRT SVSKGKEIIT IREEIEMVKN
YLKIQKIRYP DLFKAEYLIE ASCLDYKIPK LILQPLVENA LYHGIRENGK NGTIKISVHR
NNGIVIISVE DDGAGMSEKQ IEDIISNNNK SIKESFGLRG TFERIRIFYG DDEACKIESK
FGGGTKILLY INIEHKDY
//
