ID G7NBQ3_MACMU Unreviewed; 874 AA.
AC G7NBQ3; A0A1D5QEF8; A0A663DIQ7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rho GTPase activating protein 42 {ECO:0000313|Ensembl:ENSMMUP00000046427.2};
GN Name=ARHGAP42 {ECO:0000313|Ensembl:ENSMMUP00000046427.2,
GN ECO:0000313|VGNC:VGNC:99546};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000046427.2, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000046427.2}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000046427.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002799830.1; XM_002799784.2.
DR AlphaFoldDB; G7NBQ3; -.
DR SMR; G7NBQ3; -.
DR STRING; 9544.ENSMMUP00000046427; -.
DR PaxDb; 9544-ENSMMUP00000029758; -.
DR Ensembl; ENSMMUT00000060090.2; ENSMMUP00000046427.2; ENSMMUG00000022603.4.
DR GeneID; 703141; -.
DR KEGG; mcc:703141; -.
DR CTD; 143872; -.
DR VEuPathDB; HostDB:ENSMMUG00000022603; -.
DR VGNC; VGNC:99546; ARHGAP42.
DR eggNOG; KOG1451; Eukaryota.
DR GeneTree; ENSGT00940000155492; -.
DR InParanoid; G7NBQ3; -.
DR OMA; CASQERY; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000006718; Chromosome 14.
DR Bgee; ENSMMUG00000022603; Expressed in adipose tissue and 20 other cell types or tissues.
DR ExpressionAtlas; G7NBQ3; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; IEA:Ensembl.
DR GO; GO:1904694; P:negative regulation of vascular associated smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd07634; BAR_GAP10-like; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR CDD; cd12066; SH3_GRAF3; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF3; RHO GTPASE-ACTIVATING PROTEIN 42; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT REGION 575..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..259
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 584..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 98522 MW; D42CD63BAA0CCCAD CRC64;
MGLPTLEFSD SYLDSPDFRE RLQCHEIELE RTNKFIKELI KDGSLLIGAL RNLSMAVQKF
SQSLQDFQFE CIGDAETDDE ISIAQSLKEF ARLLIAVEEE RRRLIQNAND VLIAPLEKFR
KEQIGAAKDG KKKFDKESEK YYSILEKHLN LSAKKKESHL QEADTQIDRE HQNFYEASLE
YVFKIQEVQE KKKFEFVEPL LSFLQGLFTF YHEGYELAQE FAPYKQQLQF NLQNTRNNFE
STRQEVERLM QRMKSANQDY RPPSQWTMEG YLYVQEKRPL GFTWIKHYCT YDKGSKTFTM
SVSEMKSSGK MNGLVTSSPE MFKLKSCIRR KTDSIDKRFC FDIEVVERHG IITLQAFSEA
NRKLWLEAMD GKEPIYTLPA IISKKEEMYL NEAGFNFVRK CIQAVETRGI TILGLYRIGG
VNSKVQKLMN TIFSPKSPPD IDIDIELWDN KTITSGLKNY LRCLAEPLMT YKLHKDFIIA
VKSDDQNYRV EAVHALVHKL PEKNREMLDI LIKHLVKVSL HSQQNLMTVS NLGVIFGPTL
MRAQEETVAA MMNIKFQNIV VEILIEHYEK IFHTAPDPSI PLPQPQSRSG SRRTRAICLS
TGSRKPRGRY TPCLAEPDSD SYSSSPDSTP MGSIESLSSH SSEQNSTTKS ASCQPREKSG
GIPWIATPSS SNGQKSLGLW TTSPESSSRE DATKTDAESD CQSVASVTSP GDVSPPIDLV
KKGPYGLSGL KRASASSLRS ISAAEGNKSY SGSIQSLNSV GSKETPKASP NPDLPPKMCR
RLRLDTASSN GYQRPGSVVA AKAQLFENVG SPKPVSSGRQ AKAMYSCKAE HSHELSFPQG
AIFSNVYPSV EPGWLKATYE GKTGLVPENY VVFL
//
