ID G7NEH5_MACMU Unreviewed; 104 AA.
AC G7NEH5; A0A5F8ANZ6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=SOSS complex subunit C {ECO:0000256|ARBA:ARBA00014540, ECO:0000256|RuleBase:RU369016};
DE Short=SOSS-C {ECO:0000256|RuleBase:RU369016};
DE Short=SSB-interacting protein 1 {ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of single-strand DNA complex subunit C {ECO:0000256|ARBA:ARBA00030383, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of ssDNA subunit C {ECO:0000256|ARBA:ARBA00033066, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1 {ECO:0000256|ARBA:ARBA00031967, ECO:0000256|RuleBase:RU369016};
GN Name=INIP {ECO:0000313|Ensembl:ENSMMUP00000079664.1};
GN Synonyms=C9orf80 {ECO:0000313|EMBL:AFE64654.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000079664.1, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|EMBL:AFE64654.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE64654.1}, and Thymus
RC {ECO:0000313|EMBL:AFH30105.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
RN [3] {ECO:0000313|Ensembl:ENSMMUP00000079664.1}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000079664.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs). {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBUNIT: Component of the SOSS complex.
CC {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369016}.
CC -!- SIMILARITY: Belongs to the SOSS-C family.
CC {ECO:0000256|ARBA:ARBA00007829, ECO:0000256|RuleBase:RU369016}.
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DR EMBL; JU320898; AFE64654.1; -; mRNA.
DR EMBL; JU473301; AFH30105.1; -; mRNA.
DR RefSeq; XP_014972546.1; XM_015117060.1.
DR RefSeq; XP_014972547.1; XM_015117061.1.
DR STRING; 9544.ENSMMUP00000079664; -.
DR Ensembl; ENSMMUT00000094643.1; ENSMMUP00000079664.1; ENSMMUG00000007170.4.
DR GeneID; 100428127; -.
DR KEGG; mcc:100428127; -.
DR CTD; 58493; -.
DR VEuPathDB; HostDB:ENSMMUG00000007170; -.
DR eggNOG; ENOG502S23S; Eukaryota.
DR GeneTree; ENSGT00390000006366; -.
DR HOGENOM; CLU_145773_1_0_1; -.
DR OMA; MTSNPPG; -.
DR OrthoDB; 2913067at2759; -.
DR Proteomes; UP000006718; Chromosome 15.
DR Bgee; ENSMMUG00000007170; Expressed in ileum and 23 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0070876; C:SOSS complex; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0044818; P:mitotic G2/M transition checkpoint; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:UniProtKB-UniRule.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; SOSS COMPLEX SUBUNIT C; 1.
DR PANTHER; PTHR31526:SF2; SOSS COMPLEX SUBUNIT C; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 2: Evidence at transcript level;
KW DNA damage {ECO:0000256|RuleBase:RU369016};
KW DNA repair {ECO:0000256|RuleBase:RU369016};
KW Nucleus {ECO:0000256|RuleBase:RU369016};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
SQ SEQUENCE 104 AA; 11425 MW; 87B2467920C58C1E CRC64;
MAANSSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPS LNKDFRDHAE
QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE
//
