ID   G7NV91_MACFA            Unreviewed;      1634 AA.
AC   G7NV91;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Ras GTPase-activating-like protein IQGAP3 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EGM_01189 {ECO:0000313|EMBL:EHH50372.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000313|EMBL:EHH50372.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH50372.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
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DR   EMBL; CM001276; EHH50372.1; -; Genomic_DNA.
DR   eggNOG; KOG2128; Eukaryota.
DR   Proteomes; UP000009130; Chromosome 1.
DR   GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR   CDD; cd21276; CH_IQGAP3; 1.
DR   CDD; cd12207; RasGAP_IQGAP3; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.20.5.190; -; 2.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001202; WW_dom.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF10; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 4.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 4.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
FT   DOMAIN          34..149
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          671..698
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          989..1224
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
SQ   SEQUENCE   1634 AA;  184772 MW;  44DAD459B98F26D5 CRC64;
     MERRAAGPGR AAYERLTAEE MDEQRRQNVA YQYLCRLEEA KRWMEACLKE ELPSPVELEE
     SLRNGVLLAK LGHCFAPSVV PLKKIYDVEQ LRYQATGLHF RHTDNINFWL SAIAHIGLPS
     TFFPETTDIY DKKNMPRVVY CIHALSLFLF RLGLAPQIHD LYGKVKFTAE ELSNMASELA
     KYGLQLPAFS KIGGILANEL SVDEAAVHAA VLAINEAVER GVVEDTLAAL QNPSALLENL
     REPLAAIYQE ILAQAKMEKA ANARNHDERE SQDIYDHYLT QAEIQGNINH VNVHGALEVV
     DDALERQSPE VLLKALQDPA LALRGVRRDF AVWYLEQLSS DREQKAQELG LVELLEKEEV
     QAGVAAANTK GDQEQAMLHA VQRINKAIQR GVAADTVKEL MCPEAQLPPV YPVASAMYQQ
     ELAVLQRQQQ GELGQEELFV AVEMLSAVVL INRALEAQDA SGFWSSLVNP ATGLAEVEGE
     NAQRYFDALL KLRQERGMGE DFLSWNDLQA TVSQVNAQVQ EETDRVLAIS LINEALDKGS
     PEKTLSALLL PAAGLDDISL PVAPRYHLLL VAAKRQKAQV TGDPGAVLWL EEIRQGVVRA
     NQDTNTAQRM ALGVAAINQA IKEGKAAQTE RVLRNPAVAL RGVVPNCANG YQRALEGAMA
     KKQRPADSAF WVQHDMNDGT AYYFHLQTFQ GTWEQPSGCR LHTSHLTREE IQSAVTKVTA
     AYDRQQLWKA NTGFVIQLQA RLRGFLVRQK FAEHSHFLRT WLPAVIQIQA HWRGYRQRKI
     YLERLQYFKA NLDAIIKIQA WARMWATRRQ YLRRLHYFQK NVKSIVKIQA FFRARKAQDD
     YRILVHAPHP PLSVVRRFAH LLNQSQQDFL AEAELLKLQE EVVRKIRSNQ QLEQDLNIMD
     IKIGLLVKNR ITLQEVVSHC KKLTKRNKEQ LSDMMVLDKQ KGLKSLSKEK RQKLEAYQHL
     FYLLQTQPIY LAKLIFQMPQ NKTTKFMEAV IFSLYNYASS RREAYLLLQL FKTALQEEVK
     SKVEQPQDVV TGNPTVVRLV VRFYRNGRGQ SALQEILGKV IQDVLEDKVL SVHTDPVHLY
     KNWINQTEAQ TGQRSHLPYD VTPEQALSHP EVQRQLDIAL RNLLAMTDKF LVAITSSVDQ
     IPYGMRYVAK VLKATLAEKF PDATDSEVYK ASVVGNLLYY RFLNPAVVAP DAFDIVAMAA
     GGTLAAPQRH ALGAVAQLLQ HAAAGKAFSG QSQHLRVLND YLEETHLKFR KFIHRACQVP
     EPEERFAVDE YSDMVAVAKP VVYITVGELV NTHRLLLEHQ DCIASDHQDP LHELLEDLGE
     LPTIPDLIGE SIAADGHTDL SKLEVSLTLT NKFEGLEADT DDSNTRSLLL STKQLLADII
     QFHPGDTLKE ILSLSASREQ EAAHKQLMSR RQACAAQTPE PLRRHRSLTA HSLLPLAEKQ
     RRVLRNLRQL EALGLVSARN GYQGLVDELA KDIRNQHRHR HRRKAELVKL QATLQGLSTK
     TTFYEEQGDY YSQYIRACLD HLAPDSMSSG KGKKQPSLHY TAAQLLEKGV LVEIEDLPAS
     HFRNVIFDIT PGDEAGKFEV NAKFLGVDME RFQLHYQDLL QLQYEGVAVM KLFNKAKVNV
     NLLIFLLNKK FLRK
//