ID G7NW34_MACFA Unreviewed; 350 AA.
AC G7NW34;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha-3 {ECO:0000256|ARBA:ARBA00039890};
DE AltName: Full=G(i) alpha-3 {ECO:0000256|ARBA:ARBA00041800};
GN Name=GNAI3 {ECO:0000313|Ensembl:ENSMFAP00000037022.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000037022.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000037022.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000037022.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC {ECO:0000256|ARBA:ARBA00006628}.
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DR AlphaFoldDB; G7NW34; -.
DR STRING; 9541.ENSMFAP00000037022; -.
DR Ensembl; ENSMFAT00000011272.2; ENSMFAP00000037022.2; ENSMFAG00000037770.2.
DR VEuPathDB; HostDB:ENSMFAG00000037770; -.
DR eggNOG; KOG0082; Eukaryota.
DR GeneTree; ENSGT00940000153567; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000037770; Expressed in bone marrow and 13 other cell types or tissues.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF230; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-3; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 350 AA; 40236 MW; E4133DE9F70F854A CRC64;
MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLE VLENLVKAPL IIHEDGYSED
ECKQYKVVVY SNTIQSIIAI IRAMGRLKID FGEAARADDA RQLFVLAGSA EEGVMTPELA
GVIKRLWRDG GVQACFSRSR EYQLNDSASY YLNDLDRISQ SNYIPTQQDV LRTRVKTTGI
VETHFTFKDL YFKMFDVGGQ RSERKKWIHC FEGVTAIIFC VALSDYDLVL AEDEEMNRMH
ESMKLFDSIC NNKWFTETSI ILFLNKKDLF EEKIKRSPLT ICYPEYTGSN TYEEAAAYIQ
CQFEDLNRRK DTKEIYTHFT CATDTKNVQF VFDAVTDVII KNNLKECGLY
//
