ID G7NYT0_MACFA Unreviewed; 692 AA.
AC G7NYT0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Negative regulator of reactive oxygen species {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_11244 {ECO:0000313|EMBL:EHH51799.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH51799.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH51799.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001277; EHH51799.1; -; Genomic_DNA.
DR AlphaFoldDB; G7NYT0; -.
DR eggNOG; KOG0619; Eukaryota.
DR Proteomes; UP000009130; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45617; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR PANTHER; PTHR45617:SF170; SI:DKEY-90M5.4; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 12.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..692
FT /note="Negative regulator of reactive oxygen species"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003501640"
FT TRANSMEM 650..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 692 AA; 76443 MW; CC4334A34321E578 CRC64;
MELLPLWLCL GFHFLTVDWR DRSVTATAAS QGGCKLVGGD TDCRGQSLAS VPSSLPPHAR
TLILDANPLK ALWNHSLQPY PLLESLSLHS CHLERISRGA FQEQGHLRSL VLGDNCLSEN
YKETAAALHT LPGLQTLDLS GNSLTEDMAA LMLQNLSSLQ SVSLARNTIM RLDDSVFEGL
ERLRELDLQR NYIFEIEGGA FDSLTELRHL NLAYNNLPCI VDFGLTQLRS LNVSYNVLEW
FLAAGGEAAF ELETLDLSHN QLLFFPLLPQ YSKLHTLLLR DNNMGFYRDL YNTSSPREMV
AQFLLVDGNV TNITTVNLWE EFSSSDLADL RFLDMSQNQF QYLPDGFLRK MPSLSHLNLN
QNCLMTLHIR EHEPPGALTE LDLSHNQLSE LHLTPGLASC LGSLRLFNLS SNQLLGVPPG
LFANARNITT LDMSHNQISL CPLPAASDRV GPPSCVDFRN MASLRSLSLE GCGLGALPDC
PFQGTSLTSL DLSSNWGVLN GSLAPLRDVA PMLQVLSLRN MGLHSNFMAL DFSGFGNLRD
LDLSGNCLTT FPRFGGSLAL ETLDLRRNSL TALPQKAVSE QLSRGLRTIY LSQNPYDCCG
VDGWGALQQG QTVADWATVT CNLSSKIIRL AELPGGVPRD CKWERLDLGL LYLVLILPSC
LTLLVACTLI VLTFKKPLLQ VIKSRCHWSS VY
//
