ID   G7P3Y4_MACFA            Unreviewed;       346 AA.
AC   G7P3Y4;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Peripherin-2 {ECO:0000256|ARBA:ARBA00039173};
DE   AltName: Full=Retinal degeneration slow protein {ECO:0000256|ARBA:ARBA00043245};
GN   Name=PRPH2 {ECO:0000313|Ensembl:ENSMFAP00000037337.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000037337.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000037337.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000037337.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the PRPH2/ROM1 family.
CC       {ECO:0000256|ARBA:ARBA00010674}.
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DR   AlphaFoldDB; G7P3Y4; -.
DR   STRING; 9541.ENSMFAP00000037337; -.
DR   Ensembl; ENSMFAT00000011587.2; ENSMFAP00000037337.2; ENSMFAG00000037918.2.
DR   VEuPathDB; HostDB:ENSMFAG00000037918; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000157303; -.
DR   OrthoDB; 4137027at2759; -.
DR   Proteomes; UP000233100; Chromosome 4.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd03162; peripherin_like_LEL; 1.
DR   Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR   InterPro; IPR000830; Peripherin/rom-1.
DR   InterPro; IPR018498; Peripherin/rom-1_CS.
DR   InterPro; IPR042026; Peripherin_LEL.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282:SF202; PERIPHERIN-2; 1.
DR   PANTHER; PTHR19282; TETRASPANIN; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PRINTS; PR00218; PERIPHERNRDS.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00930; RDS_ROM1; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Vision {ECO:0000256|ARBA:ARBA00023305}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        101..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   346 AA;  39287 MW;  BEA3AEBAD9513EBB CRC64;
     MALLKVKFDQ KKRVKLAQGL WLMNWFSVLA GIIIFSLGLF LKIELRKRSD VMNNSESHFV
     PNSLIGMGVL SCVFNSLAGK ICYDALDPAK YARWKPWLKP YLAICVLFNI VLFLVALCCF
     LLRGSLENTL GQGLKNGMKY YRDTDTPGRC FMKKTIDMLQ IEFKCCGNNG FRDWFEIQWI
     SNRYLDFSSK EVKDRIKSNV DGRYLVDGVP FSCCNPSSPR PCIQYQITNN SAHYSYDHQT
     EELNLWVRGC RAALLSYYSS LMNSMGVVTL LIWLFEVTIT IGLRYLQTSL DCVSNPEEPE
     SESEGWLLEK SVPETWKAFL ESVKKLGKGN QVEAEGADAG QAPEAG
//